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From Science News:
DNA databases are too white, so genetics doesn’t help everyone. How do we fix that?
DNA databases need diversity for genetic research to help all people
A lack of diversity in genetic databases is making precision medicine ineffective for many people.
By Tina Hesman Saey
It’s been two decades since the Human Genome Project first unveiled a rough draft of our genetic instruction book. The promise of that medical moon shot was that doctors would soon be able to look at an individual’s DNA and prescribe the right medicines for that person’s illness or even prevent certain diseases.
That promise, known as precision medicine, has yet to be fulfilled in any widespread way. True, researchers are getting clues about some genetic variants linked to certain conditions and some that affect how drugs work in the body. But many of those advances have benefited just one group: people whose ancestral roots stem from Europe. In other words, white people.
Instead of a truly human genome that represents everyone, “what we have is essentially a European genome,” says Constance Hilliard, an evolutionary historian at the University of North Texas in Denton. “That data doesn’t work for anybody apart from people of European ancestry.”
… Often those genetic databases draw on data mainly from white participants. But race isn’t the issue. The problem is that collectively, those data add up to a catalog of genetic variants that don’t represent the full range of human genetic diversity.
When people of African, Asian, Native American or Pacific Island ancestry get a DNA test to determine if they inherited a variant that may cause cancer or if a particular drug will work for them, they’re often left with more questions than answers. The results often reveal “variants of uncertain significance,” leaving doctors with too little useful information. This happens less often for people of European descent. That disparity could change if genetics included a more diverse group of participants, researchers agree.
One solution is to make customized reference genomes for populations whose members die from cancer or heart disease at higher rates than other groups, for example, or who face other worse health outcomes, Hilliard suggests.
And the more specific the better. For instance, African Americans who descended from enslaved people have geographic and ecological origins as well as evolutionary and social histories distinct from those of recent African immigrants to the United States. Those histories have left stamps in the DNA that can make a difference in people’s health today. The same goes for Indigenous people from various parts of the world and Latino people from Mexico versus the Caribbean or Central or South America.
Researchers have made efforts to boost diversity among participants in genetic studies, but there is still a long way to go.
It’s almost as if the more science-oriented and altruistic volunteers are found among whites …
How to involve more people of diverse backgrounds — which goes beyond race and ethnicity to include geographic, social and economic diversity — in genetic research is fraught with thorny ethical questions.
To bring the public into the conversation, Science News posed some core questions to readers who watched a short video of Hilliard explaining her views.
Again and again, respondents to our unscientific survey said that genetic research is important for improving medical care. But our mostly white respondents had mixed feelings about whether the solution is customized projects such as Hilliard proposes or a more generalized effort to add variants to the existing human reference genome. Many people were concerned that pointing out genetic differences may reinforce mistaken concepts of racial inferiority and superiority, and lead to more discrimination.
In other words, the white readers of Science News worry that more genetic studies on more diverse people would prove The Bell Curve right, and that would the worst thing imaginable.
Why is genetics so white?
Some of our readers asked how genetic research got to this state in the first place. Why is genetic research so white and what do we do about it? …
All humans have basically the same DNA. Any two people are 99.9 percent genetically identical.
Is that number that was popular around 2000 still accurate?
… But the 0.1 percent difference between individuals — all the spelling variations, typos, insertions and deletions sprinkled throughout the text of the human instruction book — contributes to differences in health and disease.
… In 2018, people of European ancestry made up more than 78 percent of GWAS participants, researchers reported in Cell in 2019. That’s an improvement from 2009, when 96 percent of participants had European ancestors, researchers reported in Nature. …
Most of the research funded by the major supporter of U.S. biomedical research, the National Institutes of Health, is done by scientists who identify as white, says Sam Oh, an epidemiologist at the University of California, San Francisco. Black and Hispanic researchers collectively receive about 6 percent of research project grants, according to NIH data.
As usual in 2020 articles about race, Asians are ignored, even when quoting an Asian.
“Generally, the participants who are easier to recruit are people who look like the scientists themselves — people who share similar language, similar culture. It’s easier to establish a rapport and you may already have inroads into communities you’re trying to recruit,” Oh says.
When origins matter
Hilliard’s hypothesis is that precision medicine, which tailors treatments based on a person’s genetic data, lifestyle, environment and physiology, is more likely to succeed when researchers consider the histories of groups that have worse health outcomes. For instance, Black Americans descended from enslaved people have higher rates of kidney disease and high blood pressure, and higher death rates from certain cancers than other U.S. racial and ethnic groups.
In her work as an evolutionary historian studying the people and cultures of West Africa, Hilliard may have uncovered one reason that African Americans descended from enslaved people die from certain types of breast and prostate cancers at higher rates than white people, but have lower rates of the brittle-bone disease osteoporosis. African Americans have a variant of a gene called TRPV6 that helps their cells take up calcium. Overactive TRPV6 is also a hallmark of those breast and prostate cancers that disproportionately kill Black people in the United States.
The variant can be traced back to the ancestors of some African Americans: Niger-Congo–speaking West Africans. In that part of West Africa, the tsetse fly kills cattle, making dairy farming unsustainable. Those ancestral people typically consumed a scant 200 to 400 milligrams of calcium per day. The calcium-absorbing version of TRPV6 helped the body meet its calcium needs, Hilliard hypothesizes. Today, descendants of some of those people still carry the more absorbent version of the gene, but consume more than 800 milligrams of calcium each day.
Assuming that African American women have the same dietary need for calcium as women of European descent may lead doctors to recommend higher calcium intake, which may inadvertently encourage growth of breast and prostate cancers, Hilliard reported in the Journal of Cancer Research & Therapy in 2018.
“Nobody is connecting the dots,” Hilliard says, because most research has focused on the European version of TRPV6. …
Recruiting people from all over the world to participate in genetic research might seem like the way to increase diversity, but that’s a fallacy, Hilliard says. If you really want genetic diversity, look to Africa, she says.
Humans originated in Africa, and the continent is home to the most genetically diverse people in the world. Ancestors of Europeans, Asians, Native Americans and Pacific Islanders carry only part of that diversity, so sequencing genomes from geographically dispersed people won’t capture the full range of variants.
But a lot of the genetic diversity in sub-Saharan Africans doesn’t do much. That’s why they kind of look alike.
… Some countries have begun building specialized reference genomes. China compiled a reference of the world’s largest ethnic group, Han Chinese. A recent analysis indicates that Han Chinese people can be divided into six subgroups hailing from different parts of the country. China’s genome project is also compiling data on nine ethnic minorities within its borders. Denmark, Japan and South Korea also are creating country-specific reference genomes and cataloging genetic variants that might contribute to health problems that their populations face. Whether this approach will improve medical care remains to be seen. …
One big drawback to Hilliard’s proposal may be social rather than scientific, according to some Science News readers.
Many respondents to our survey expressed concern that even well-intentioned scientists might do research that ultimately increases bias and discrimination toward certain groups. As one reader put it, “The idea of diversity is being stretched into an arena where racial differences will be emphasized and commonalities minimized. This is truly the entry to a racist philosophy.”
If humanity is not allowed to collect massive amounts of genetic data on non-whites, then The Bell Curve can’t be proven true. And that must be the human race’s highest priority, preserving the tiny bit of self-esteem that blacks have at present.
Another reader commented, “The fear is that any differences that are found would be exploited by those who want to denigrate others.” Another added, “The idea that there are large genetic differences between populations is a can of worms, isn’t it?” …
And issues of privacy become a big deal for small groups, such as the 574 recognized Native American tribal nations in the United States, or isolated religious or cultural groups such as the Amish or Hutterites. If one member of such a group decides to give DNA to a genetic project, that submission may paint a genetic portrait of every member of the group. Such decisions shouldn’t be left in individual hands, Tsosie says; it should be a community decision.
My impression is that the Amish enthusiastically participate in genetic research. From Wikipedia:
Amish represent a collection of different demes or genetically closed communities.[1] Since almost all Amish descend from about 500 18th-century founders, genetic disorders that come out due to inbreeding exist in more isolated districts (an example of the founder effect). These disorders include dwarfism (Ellis–van Creveld syndrome),[2] Angelman syndrome,[3] and various metabolic disorders,[4] as well as an unusual distribution of blood types.[5] Some of these disorders are quite rare, or unique, and are serious enough to increase the mortality rate among Amish children. The majority of Amish accept these as “Gottes Wille” (God’s will); they reject use of preventive genetic tests prior to marriage and genetic testing of unborn children to discover genetic disorders. However, Amish are willing to participate in studies of genetic diseases. Their extensive family histories are useful to researchers investigating diseases such as Alzheimer’s, Parkinson’s, and macular degeneration.
Back to Science News:
Hilliard says minorities’ resistance to participating in genetic research is about more than a fear of being singled out; it’s the result of being experimented on but seeing medical breakthroughs benefit only white people.
The use of DNA from relatives to find murderers and rapists in recent years probably discourages blacks. To whites, the idea of my DNA being used to arrest some 4th cousin for some ghastly crime seems like justice. To blacks, it seem like a way to put a first cousin who is turning his life around in the pen.
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Sequence everyone who is “justice involved”. That ought to cover it.
Testing of the “involved” is now near universal. There has been plenty of ߘlack DNA collected by this point.
From 2013 case:
“The U.S. Supreme Court ruled Monday that police can routinely take DNA samples from people who are arrested but not yet convicted of a crime, and see if the DNA matches any samples from unsolved crimes in a national database.
The 5-to-4 decision split the court's conservative and liberal blocs, with conservative Justice Antonin Scalia authoring a fiery dissent.
Twenty-eight states and the federal government have enacted laws that provide for automatic DNA testing of arrestees.”Replies: @AndrewR, @YetAnotherAnon
Science is racist.
Math is racist.
Logic is racist.
Facts are racist.
Mozart was racist.
Shakespeare was racist.
Monet was racist.
Grammar is racist.
However, emptying a magazine more or less in the general direction of peeps is not racist.
Damn.
All this debt and most people have only seen a couple grand tops in NEETbux.Replies: @guest007
The actual U.S. debt, which includes obligations, was calculated/estimated to be $222 trillion in 2012 by an economist at Boston University.
Of concern, the US’ economic growth rate has been under attack, by government interventions, for generations. Despite its amazing resilience, at some point it doesn’t bounce back (the real flattening of the curve).
Europeans, Asians, and Hispanics are descendants of people smart enough to get out of sub-Saharan Africa.
FIFY Science News.
And please note that inbred shitkickers, the Amish, have a better grasp of genetics than our diverse Blacks.
The Henrietta Lacks story is instructive. A great injustice has been committed, supposedly, because her cancer cells have benefited researchers and pharmaceutical companies and, of course, cancer patients — without giving Lacks’s family a piece of the action.
I understand that multitude of descendants want some cash because of this supposed great injustice. But should the researchers have just foregone the use of this cell line? It may have great value to medical science but a few microscopic cancer cells were really of no value to Lacks because there was no market to sell them. By the way, the cells were obtained in the course of Lacks' treatment for cancer at some place called Johns Hopkins.Replies: @AndrewR
Was her life damaged by culturing her cancer cells? Was the quality of care damaged?
It's the equivalent harm of someone taking my hair clippings and making fake mustaches out of them. I wasn't going to do anything with it anyways, so go ahead.Replies: @Patriot, @International Jew, @Anonymous
Given that the Narrative holds that race is just a “social construct,” this shouldn’t matter. After all, aren’t we all basically identical aside from “skin color,” which is just a random thing that’s not tied to anything biological or genetic anyway? If that’s true, it shouldn’t matter what the sample of the population in DNA databases looks like. In fact, we could probably just take DNA from one person and work off that. I don’t make the rules.
1) Whites are ultimately responsible for all problems that have ever or will ever exist, dating back at least to the Permian-Triassic extinction event.
2) Race doesn't exist and it doesn't matter except insofar as white people (whom the woke have no trouble labelling and identifying) make it matter.
3) Anything that actually improves the well-being of non-whites is bad if it can be used to further White Supremacy
Etc
In the end it doesn't matter. These people are piloting the plane and they're on a suicide mission, but they make kamikaze pilots and Islamist terrorists all seem quite rational in comparison. We are not going to talk our way out of this, and (sorry, Sailer), we are definitely not going to snark our way out of this.
Just as 1984 had a 'dual system of astronomy' Woke 'science' has a dual system of race. [It's a bit like the proverbial shady business which maintains two sets of account ledgers, ie a public one with false numbers for the stockholders to see, and a second hidden account ledger containing the true numbers for the director's use.]
As helpfully expounded upon by O'Brien when torturing Winston:Replies: @FLgeezer
I wonder if that rocket scientist is also now pursuing a career as an “ evolutionary historian ”. You get paid to write about science without needing to have the brains needed to actually do science.Replies: @Barnard
*Henrietta Lacks
OT and apologies, but one of the commenters here recently posted a picture of an app that lets you pretend you’re burning books by dragging them into a fire. Can anyone help me find the link? I’m turning up nothing.
OT armed robbery at Beverly Hills fancy restaurant. Three young men read black shot a woman and took a half million watch.
Defund the police.
The prices don’t seem ridiculously high, albeit not as reasonable as my local Olive Garden. And at my Olive Garden there’s indoor seating which poses less risk than being out in the open where some bandits can force me to surrender my Richard Mille watch.Replies: @Muggles, @Rob
Thanks!
LOL. I’ve seen that guy on YouTube:
For some perspective, we apparently share around 99% of our DNA with chimps and bonobos.
https://phys.org/news/2020-12-genomes-pathways-chimpanzee-bonobo-divergence.html
https://thednatests.com/how-much-dna-do-humans-share-with-other-animals/Replies: @Polistra
https://genetics.thetech.org/original_news/news38
Then there are indels (insertions and deletions). I don't know of a better number though and don't have time to search now.
https://www.scientificamerican.com/article/is-junk-dna-what-makes-humans-unique/
I have only done this once.Replies: @Muggles
“It is racist to rely on volunteer DNA data” means it won’t be voluntary much longer.
“It is racist to analyze DNA data” means you plebes won’t ever have access to that hoard of DNA data.
[respondents to a survey agreed that] genetic research is important for improving medical care.
Ask them “What’s the average, daytime high temperature on Mars, at the Equator, on the planet’s longest day of the year?”, and you’re likely to receive all sorts of (numerical) answers, but not the correct one: “I haven’t the foggiest idea.”
Here is some more perspective: 98% with a pig
https://thednatests.com/how-much-dna-do-humans-share-with-other-animals/
Last post on this, but the “99.9% similar” line is very misleading. The human genome is massive – it has around 3 billion base pairs – so a 0.1% would still mean a 3 million base pair difference. You only need a handful of genes, if they are consistently found in race over another, to make a big difference in something like intelligence. There can be a lot of genetic variation in that 0.1%
3% of the DNA of Caucasians is from Neanderthals....while Sub-Saharan Africans have zero Neanderthal DNA. Africans have ghost archaic introgression from another archaic hominin. It is quite clear that Caucasians do not share 99% of our DNA with Africans, since Caucasians are a hybrid species resulting from the interbreeding of Neanderthals and homo sapiens While Africans were once thought to be pure homo sapiens we now know they are also a hybrid species of homo sapien combined with a different archaic hominins.
Also, as I've observed firsthand, a white man and white woman will produce a white child. Blacks follow similar patterns. I think Asians and Amerinds do the same. Weird, isn't it?
Yet, these ignorant SJW and media whores tell us that the ~ 3,000,000 nucleotide differences in the average person is meaningless???? Lying, deceiving, Marxist all of them.
Note also that the 3,000,000 base differences are not distributed randomly across the thousands of different human populations, nor the ?dozen? or so living major human races. Because of hundreds or thousands of years of isolated inbreeding, each population/race has evolved its own unique set if genetic differences, shared only among that single population. It's the UNIQUE COMBINATION of genes that give each race their particular combination of traits.
Same in the card game poker: it's not that you hold a 10 of spades, its the particular COMBINATION of cards that gives you a winning or losing hand -- for example, a 7, 8, 9, 10, jack straight -- or four 10's.
This problem could be solved with a reference genome for each race. Except that race is a social construct with no scientific meaning, so that is impossible.
For people of lower education, science looks more superstitious – and the karma that rolls with it is more readily perceived as being – bad. – Here is a parallel to woke thinking.
Woke reasoning = a regression to the needy. The thinking of the needy – something that can be quite easily explained from the woke’s perspective. – Two mindsets match.
“Whites Are Most Likely to Volunteer Their DNA” to globalist corporations dedicated to destroying them culturally and physically.
Yet another symptom of self-destructive, evolutionarily maladaptive decadence, at least among “educated” whites.
LOL – “altruism” toward billionaires and MNCs on the part of those being liquidated. Just the way the system likes it, the victims’ own minds a weapon in the hands of the oppressor.
This woman claims to want to have treatment by race…. however, IRL when the medical community DOES treatment by race, it’s accused of being racist, like with the kidney function formula we’ve discussed before:
https://www.kidney.org/atoz/content/race-and-egfr-what-controversy
Instead we should just do it by training AI on whole genomes.
i’m going to get the language wrong, but there’s that whole thing how the variations of a single gene don’t tell races apart but that specific patterns of differences across the genome do.
That means that you don’t have to have your treatment be a function of (alelle, race, sub-race, area of origin).
Instead just train an AI on the data from your trial on (efficacy, full genome) and then you can base your decisions on the full genome of the patient instead. (race, sub-race, area of origin) are encoded in the DNA in both cases but it’ll be entirely opaque to us. That way it’s not racist.
(of course the whole “all AI is racist” is already a thing so maybe it wouldn’t help after all )
Yes. Another example is the treatment of congestive heart failure. The drug BiDil (a combination of two common medications in a fixed proportion) doesn't improve outcomes for white patients but does for African-American patients (compared to the standard of care).
Here is a 2017 anti-BiDil article based on messaging from the woke ProPublica collective. You have to scroll to the third-to-last paragraph for the grudging admission that it saves lives:Tellingly, that's immediately followed byThe most recent interesting update I could find is also from 2017, Clinical Effectiveness of Hydralazine-Isosorbide Dinitrate [BiDil] in African-American Patients With Heart Failure.Details: VA physicians looked at the records of 5,200 African-Americans with severe heart failure. Adjusted mortality at 18 months was 22.1% for BiDil patients, versus 25.2% receiving the non-BiDil standard of care (p = 0.009). The adjusted hazard ratio: 0.85 (95% confidence interval: 0.73 to 1.00). So BiDil was modestly effective in this cohort of very sick heart patients.Replies: @James N. Kennett
Strongly agree with your first paragraph. I wonder if these people realize how inconsistent that is.
Science is as White as the band Oingo Boingo!
slightly off-topic, but seems that American liberals are running out of hominids to cancel:
“Sequence everyone who is “justice involved”.”
Testing of the “involved” is now near universal. There has been plenty of ߘlack DNA collected by this point.
From 2013 case:
“The U.S. Supreme Court ruled Monday that police can routinely take DNA samples from people who are arrested but not yet convicted of a crime, and see if the DNA matches any samples from unsolved crimes in a national database.
The 5-to-4 decision split the court’s conservative and liberal blocs, with conservative Justice Antonin Scalia authoring a fiery dissent.
Twenty-eight states and the federal government have enacted laws that provide for automatic DNA testing of arrestees.”
There, by the way, is the answer to the shortage of minorities volunteering their DNA.
"Why is genetic research so white and what do we do about it?"
Er... start your own research and ask people to donate?Replies: @Bardon Kaldian, @Templar
The knots that woke people tie themselves into in order to not step afoul of the taboos du jour are beyond description. Their primary axioms seem to be
1) Whites are ultimately responsible for all problems that have ever or will ever exist, dating back at least to the Permian-Triassic extinction event.
2) Race doesn’t exist and it doesn’t matter except insofar as white people (whom the woke have no trouble labelling and identifying) make it matter.
3) Anything that actually improves the well-being of non-whites is bad if it can be used to further White Supremacy
Etc
In the end it doesn’t matter. These people are piloting the plane and they’re on a suicide mission, but they make kamikaze pilots and Islamist terrorists all seem quite rational in comparison. We are not going to talk our way out of this, and (sorry, Sailer), we are definitely not going to snark our way out of this.
And the author’s feeble attempt to explain away that 800-pound gorilla, lest we ask an inconvenient question:
Testing of the “involved” is now near universal. There has been plenty of ߘlack DNA collected by this point.
From 2013 case:
“The U.S. Supreme Court ruled Monday that police can routinely take DNA samples from people who are arrested but not yet convicted of a crime, and see if the DNA matches any samples from unsolved crimes in a national database.
The 5-to-4 decision split the court's conservative and liberal blocs, with conservative Justice Antonin Scalia authoring a fiery dissent.
Twenty-eight states and the federal government have enacted laws that provide for automatic DNA testing of arrestees.”Replies: @AndrewR, @YetAnotherAnon
Lol it cracks me up how “conservatives” always talk about wanting more freedom and less government, but apparently are ok with the government forcibly making a DNA database of any unfortunate soul that a pig might happen to arrest for any reason.
We could restrict the police to taking DNA only from black suspects. Would that make it all better?
Math is racist.
Logic is racist.
Facts are racist.
Mozart was racist.
Shakespeare was racist.
Monet was racist.
Grammar is racist.
However, emptying a magazine more or less in the general direction of peeps is not racist.Replies: @Luzzatto, @Hannah Katz
Democrats can not decide on whether Ludwig Van Beethoven was a White Supremacist who needs to be Cancel Cultured or a We Wuz Kangz Black African Nubian Wakandian Ebony God King who needs to be celebrated as an example of Black excellence. Democrats go back and fourth between the two. There needs to be a meme with two buttons where the sweaty guy can not decide which button to push!
This. The big trend across the board is the elimination of information and the imposition of gatekeeping mechanisms. Don’t respect our fake experts? Fine, we’ll impose censorship and licensing and sign-off requirements, and you’ll effectively have to. Some of Charles Murray’s most emotional tweets (both joyful in escape and angry in complaint) concern the monopoly-like control of access to academic papers, which has been circumvented by technology recently, but which will surely be restored as Big Tech does all it can to fight the Phantom Nazis.
Of course as with anything like this there is a degree of dodginess; don't let it install anything on your computer, obviously. But if you want to freely access the scientific literature, well, the Kazakhs believe you should be able to.Replies: @SimpleSong
Defund the police.Replies: @Luzzatto, @Luzzatto, @AndrewR, @Anonymous
I wonder how often Wakandian people from South Los Angeles drive all the way to Beverly Hills to commit armed robbery?
Defund the police.Replies: @Luzzatto, @Luzzatto, @AndrewR, @Anonymous
I wonder how often Wakandian people from South Los Angeles drive all the way to Beverly Hills to commit armed robbery?
Testing of the “involved” is now near universal. There has been plenty of ߘlack DNA collected by this point.
From 2013 case:
“The U.S. Supreme Court ruled Monday that police can routinely take DNA samples from people who are arrested but not yet convicted of a crime, and see if the DNA matches any samples from unsolved crimes in a national database.
The 5-to-4 decision split the court's conservative and liberal blocs, with conservative Justice Antonin Scalia authoring a fiery dissent.
Twenty-eight states and the federal government have enacted laws that provide for automatic DNA testing of arrestees.”Replies: @AndrewR, @YetAnotherAnon
In the UK arrestees routinely have DNA samples taken and kept no matter what the outcome of the arrest or any trial.
There, by the way, is the answer to the shortage of minorities volunteering their DNA.
“Why is genetic research so white and what do we do about it?”
Er… start your own research and ask people to donate?
Where an individual is arrested for, but not charged with, a qualifying offence, their DNA profile and fingerprint record will normally be deleted. However, the police can apply to the Biometrics Commissioner for permission to retain their DNA profile and fingerprint record for a period of up to 3 years.4 Apr 2013
www.gov.uk › publications › protec...
Protection of Freedoms Act
It’s not that far to Beverly Hills from the Hood. It’s only about 5 miles from West Adams to the corner of Rodeo and Wilshire. Beverly Hills has always relied on armed security rather than distance for protection.
No worries … mRNA “vaccines” will make DNA databases moot.
From 2011:
Participation in Genetic Testing Research Varies by Social Group
https://www.karger.com/Article/Fulltext/294277
They attempted to discern level of trust in medical staff and institutions, and blacks didn’t show much difference compared to whites. This kind of negates the Tuskegee hypothesis, although the speculate that there might be a distrust in how genetic information might be used (Steve’s DNA snitch idea?, but this doesn’t seem likely to me).
I wonder what the crime rate in Los Angeles would be like if Maxine Waters district did not exist?
People are not 99.9% identical. The true figure is closer to 96%. The 99.9% calculation ignores so- called junk DNA and random repeating sequences, or having two copies of a gene verse one copy, which we are learning do have effects on human health. https://genetics.thetech.org/original_news/news38
https://thednatests.com/how-much-dna-do-humans-share-with-other-animals/Replies: @Polistra
And never forget: about 60% with bananas.
https://www.businessinsider.com/comparing-genetic-similarity-between-humans-and-other-things-2016-5#even-bananas-surprisingly-still-share-about-60-of-the-same-dna-as-humans-8
Which, as it happens, is a favorite snack of chimps and bonobos. So, we’ve all come full circle here. And I think we’ve all learned something. Especially if “nothing” counts as something.
I thought that race was a social construct having no basis in biological reality. So, why all this whining?
Ask them “What’s the average, daytime high temperature on Mars, at the Equator, on the planet’s longest day of the year?”, and you’re likely to receive all sorts of (numerical) answers, but not the correct one: “I haven’t the foggiest idea.”Replies: @Polistra
*sfx: buzzer*
Overfitting more like. Blacks are have high testosterone, and that is why all the prostrate cancer. Inuit have calcium concentrating adaptations too https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417586/
Few black rapists have the organised M,O. of the Original Night Stalker or BTK leading double lives. Most black perps are probably career criminals shot dead at their day job (like Stinky the 70’s Berkley rapist) or doing life for a similar crime by now. Due to being testosterone crazed, those fellows do stuff in their early twenties knowing full well that they are probably going to be murdered or be doing life without the possibility of parole by the end of their third decade, while their chaotic lifestyle means they are debilitated with various medical conditions by their fifties.
I think that 23 and me stuff is a business that people pay for, and maybe blacks are just not that interested, or affluent. White crime and taking the trouble to provide DNA.
https://twitter.com/disclosetv/status/1367528571380637697Replies: @AndrewR, @Anonymous, @Abolish_public_education, @Hypnotoad666, @guest007
Money printer go brrrrrrrrrrrr
All this debt and most people have only seen a couple grand tops in NEETbux.
Why don’t Asian and African countries run their own genome projects? Ok, strike Africa.
apparently Neanderthals and humans share 99.7% of DNA, so their “thinking” on mask mandates deserves genetic respect, Mr President?
There, by the way, is the answer to the shortage of minorities volunteering their DNA.
"Why is genetic research so white and what do we do about it?"
Er... start your own research and ask people to donate?Replies: @Bardon Kaldian, @Templar
I like this.
By the way, re “only skin deep” thing….
I’ve posted a few comments on the Unz article on Jews & pornography. To make some sense of it, I’ve searched sites on porn stats; also, I read stats on porn stars, their wealth etc. etc.
Porn – visual, and especially Internet – is one the best examples how looks matter. Female porn stars, white, all look the same to me (they certainly have undergone cosmetic surgeries galore). The same goes for fetishes like ethnic/racial porn.
Simply- race is basically looks of a collective. One can go into genes, IQ, physiology,…. but at the most basic, human groups group themselves around collective looks plus culture. And within a collective, those who look good or great, have enormously more chances in life.
Looks is not less than 50% of your identity, whether you like it or not.
It's the thrust of the "whether you like it or not" at the end that's interesting. You don't think that folks can "look past" the skin and the flesh to see the spirit or the joy a person is?Replies: @Bardon Kaldian
Defund the police.Replies: @Luzzatto, @Luzzatto, @AndrewR, @Anonymous
Black Looters Matter
“To blacks, it seem like a way to put a first cousin who is turning his life around in the pen.”
Especially when the first cousin dindo nuffin.
Math is racist.
Logic is racist.
Facts are racist.
Mozart was racist.
Shakespeare was racist.
Monet was racist.
Grammar is racist.
However, emptying a magazine more or less in the general direction of peeps is not racist.Replies: @Luzzatto, @Hannah Katz
Correction: Grammar be racist.
Tina:
Whites are also more likely to donate their body to science (medical schools), volunteer for amedical research protocol when they have a disease , do their own research in learn about the disease they have and learn about less common treatments, or even volunteer at a hospital or other medical facility.
A secondary question is why don’t the highly educated Asians who live in the U.S. act more like middle class whites when it comes to healthcare?
Just a guess.Replies: @guest007
Answer: Because there's no such thing as magic dirt, you fool. They're not Whites with yellow skin. They are a separate and alien race. Their history and genetics (which together create culture) are utterly different from that of White Europeans, and they remain different regardless of where they are born or raised (or profit at the expense of the locals). They will not donate anything of their own nor risk anyone of their own kind unless it's for the benefit of themselves (and even then it's questionable). They have no concept of the common good nor care for society as a whole - their sole concern is how well they and their immediate family fare. Once excellent visual example as how their interior home may be spotless and elegant, while their street (or neighborhood, or overall city) may well be like a sewer. Sh*tholes are made, not born, by people genetically predisposed to low trust and high ethnocentrism.
In addition to what Dieter Kief has mentioned some studies suggest fatalism prevents blacks from participating in medical screening.
Also keep in mind that only 1-2% of the genome actually codes for genes. That means a 0.1% variation in the genome could be a difference in 5-10% of the actual genes.
https://www.kidney.org/atoz/content/race-and-egfr-what-controversy
Instead we should just do it by training AI on whole genomes.
i'm going to get the language wrong, but there's that whole thing how the variations of a single gene don't tell races apart but that specific patterns of differences across the genome do.
That means that you don't have to have your treatment be a function of (alelle, race, sub-race, area of origin).
Instead just train an AI on the data from your trial on (efficacy, full genome) and then you can base your decisions on the full genome of the patient instead. (race, sub-race, area of origin) are encoded in the DNA in both cases but it'll be entirely opaque to us. That way it's not racist.
(of course the whole "all AI is racist" is already a thing so maybe it wouldn't help after all )Replies: @ic1000, @res
Re: reality of different meanings of kidney function clinical tests based on the race of the patient
Yes. Another example is the treatment of congestive heart failure. The drug BiDil (a combination of two common medications in a fixed proportion) doesn’t improve outcomes for white patients but does for African-American patients (compared to the standard of care).
Here is a 2017 anti-BiDil article based on messaging from the woke ProPublica collective. You have to scroll to the third-to-last paragraph for the grudging admission that it saves lives:
Tellingly, that’s immediately followed by
The most recent interesting update I could find is also from 2017, Clinical Effectiveness of Hydralazine-Isosorbide Dinitrate [BiDil] in African-American Patients With Heart Failure.
Details: VA physicians looked at the records of 5,200 African-Americans with severe heart failure. Adjusted mortality at 18 months was 22.1% for BiDil patients, versus 25.2% receiving the non-BiDil standard of care (p = 0.009). The adjusted hazard ratio: 0.85 (95% confidence interval: 0.73 to 1.00). So BiDil was modestly effective in this cohort of very sick heart patients.
Not enough genomic info on blacks? For a potential solution we could look at the famous Barney Hill case — the black guy (played by James Earl Jones in the movie) who was abducted and probed God-knows-where by space aliens. I think you can follow my line of thought here …
https://en.wikipedia.org/wiki/The_UFO_Incident
the 99.9% figure is 100% false. The 99% figure is based on protein coding DNA, which is just 2% of our DNA. 98% was once considered Junk DNA but we now realize that 80% of the “junk DNA”carries out some sort of function. When the entire DNA of humans is compared, not just the small percentage of protein coding DNA, we discover that humans typically share less than 90% of our DNA if we analyze the full genome, including random repeating sequences and junk DNA. https://www.discovermagazine.com/health/our-cells-are-filled-with-junk-dna-heres-why-we-need-it
3% of the DNA of Caucasians is from Neanderthals….while Sub-Saharan Africans have zero Neanderthal DNA. Africans have ghost archaic introgression from another archaic hominin. It is quite clear that Caucasians do not share 99% of our DNA with Africans, since Caucasians are a hybrid species resulting from the interbreeding of Neanderthals and homo sapiens While Africans were once thought to be pure homo sapiens we now know they are also a hybrid species of homo sapien combined with a different archaic hominins.
Can of worms? It’s more like a 50-gallon drum of rattlesnakes. And it’s already open.
Better off pretending it doesn’t exist, eh?
Yeah, the 99.9 % identical DNA is responsible for the Bell Curve of height distribution, but little else. I think Steven Pinker blew that one up.
Tina Hesman Saey is actually pretty knowledgeable and smart. Her article correctly covers the key material. It’s the spin and packaging that provokes eye-rolls.
Steve has speculated that the higher-quality NYT reporters try to provide facts and context, so that diligent and sharp readers can puzzle things out themselves (e.g. Upside-Down news stories). Who can say whether this is vestigial journalistic ethics, or whether it’s the best realist reporters can manage, given the editors they have to work under.
Saey could have bracketed paragraph two with [HINT] and [/HINT].
1. That promise, known as precision medicine, has yet to be fulfilled in any widespread way.
So in terms of patient care, none of what I’m going to tell you matters. Yet.
2. True, researchers are getting clues about some genetic variants linked to certain conditions and some that affect how drugs work in the body.
Once understood and implemented, this stuff probably will matter for patient care.
3. But many of those advances have benefited just one group… white people.
Ignore #1, ignore #3, or believe two contradictory ideas at once. Your choice, reader.
https://twitter.com/disclosetv/status/1367528571380637697Replies: @AndrewR, @Anonymous, @Abolish_public_education, @Hypnotoad666, @guest007
That listed debt is just the outright debt. Which, btw, is now over $28 trillion (nb: last month it was $27 trillion and change). https://usdebtclock.org/
The actual U.S. debt, which includes obligations, was calculated/estimated to be $222 trillion in 2012 by an economist at Boston University.
Not to fret.
Just as 1984 had a ‘dual system of astronomy’ Woke ‘science’ has a dual system of race. [It’s a bit like the proverbial shady business which maintains two sets of account ledgers, ie a public one with false numbers for the stockholders to see, and a second hidden account ledger containing the true numbers for the director’s use.]
As helpfully expounded upon by O’Brien when torturing Winston:
https://www.local10.com/news/local/2021/03/06/miami-native-playing-big-role-in-nasas-historic-mission-to-mars/
I've posted a few comments on the Unz article on Jews & pornography. To make some sense of it, I've searched sites on porn stats; also, I read stats on porn stars, their wealth etc. etc.
Porn - visual, and especially Internet - is one the best examples how looks matter. Female porn stars, white, all look the same to me (they certainly have undergone cosmetic surgeries galore). The same goes for fetishes like ethnic/racial porn.
Simply- race is basically looks of a collective. One can go into genes, IQ, physiology,.... but at the most basic, human groups group themselves around collective looks plus culture. And within a collective, those who look good or great, have enormously more chances in life.
Looks is not less than 50% of your identity, whether you like it or not.Replies: @Polemos
Does a person have to stay constrained to thinking of their self-defining collective as their race, or “looks of a collective”? For example, maybe someone over time notices that within the eyes of those who have awakened to a spiritual reality far exceeding the material world stirs a genuine, living brightness and that such brightness is transcultural, even transspecific, so that they begin to self-define from the collective of those whose eyes show the living light. Do you think this person is just a theoretical abstraction (i.e., everyone is always already actually thinking about race) or do you think this kind of reassessment of who and what one is towards transcending one’s body (and those of others) is an option?
It’s the thrust of the “whether you like it or not” at the end that’s interesting. You don’t think that folks can “look past” the skin and the flesh to see the spirit or the joy a person is?
True. No human has ever given birth to a chimp. A baby with too many mutations will just die, it will never come out as a chimpanzee.
Also, as I’ve observed firsthand, a white man and white woman will produce a white child. Blacks follow similar patterns. I think Asians and Amerinds do the same. Weird, isn’t it?
Nah, they just don’t like it because white DNA along with anthropology and archeology just prove we whiteys were kings all the way back into the ice age. The black folks were still ancient hominids, if that. Apparently blacks crave their diaper rash from incessant arse kissing.
Sorry black folks, I can only say the very respected Clarence Thomas’ name so many times to ignore the current lack content of your collective character. Who’d ever have thought affirmative action was just the initial means to infantize swatches of people? Think no, just look at modern white women. Apparently working hard rather than token hiring builds true character. You can do it, but won’t at this point. Calling me a name since it is so much easier. Sad.
Do you really want your kidneys donated to some hoodrat who lost his in a shooting, just so he can live long enough to knock up some sheboon?
Stop donating blood and don’t sign that organ donation form on your driver’s license.
It’s a false dichotomy that if one knows the truth about race it ipso facto translates into abuse between peoples, ethnicities, and races, etc.
Healthy minded individuals of good will don’t abuse others as individuals simply on physical and cognitive differences between them. It can be the same between the various races and ethnicities.
To the extent it’s not, most definitely work on fixing that, but don’t pretend (ie lie) that ‘everyone is the same’, ie ‘equal’ which resolves nothing, and in reality compounds problems.
The below is not the answer when it comes to race…
Defund the police.Replies: @Luzzatto, @Luzzatto, @AndrewR, @Anonymous
From TMZ:
Here’s the menu: https://www.ilpastaiobeverlyhills.com/our-menu/
The prices don’t seem ridiculously high, albeit not as reasonable as my local Olive Garden. And at my Olive Garden there’s indoor seating which poses less risk than being out in the open where some bandits can force me to surrender my Richard Mille watch.
Or a large sign that says "rob me, I have a half a million in jewelry on me."
I don't mind rich people. Rich and stupid, yes.
No one will pay retail for a stolen watch. Everyone who is the target market for them knows that a watch was stolen, so when a shady guy is offering one, just one, he does not have an inventory, you can be pretty sure it is the stolen one. Not to mention, the skells that stole it probably do not know anyone with even tens of thousands of dollars to spend on a fancy watch. It kinda seemed like there were a lot of black celebs there. Is it a place popular with blacks?
The fact that there is a market for luxury items that expensive is proof we need wealth redistribution. Extremely unequal societies seem to end end up with sterile consumption of wealth in luxury items that rich people use to signal to other rich people that they are rich people. It seems to be a failure mode caused by extreme inequality.
To stay on iSteve themes, a chunk of inequality is caused by immigration lowering wages and raising rents and home prices (price of bread goes up: inflation price of a home goes up:wealth)
Yeah. Are we supposed to celebrate this illiterate, cousin-marrying woman as a leading figure in the field of medical science or are we supposed to be outraged that her cancer cells were used without her consent? (And let’s be honest, if her consent had been sought, could she have even understood to what she was being asked to consent?)
I understand that multitude of descendants want some cash because of this supposed great injustice. But should the researchers have just foregone the use of this cell line? It may have great value to medical science but a few microscopic cancer cells were really of no value to Lacks because there was no market to sell them. By the way, the cells were obtained in the course of Lacks’ treatment for cancer at some place called Johns Hopkins.
Quite right. A black juror on O.J. Simpson’s trial for murder was booted for breaking the rules and interviewed briefly. He was asked how he had been leaning on the verdict, and if the DNA evidence in particular was damning. As best as I can remember his response was; “Dat DNA stuff don’t mean nothing, everybody got dat DNA stuff”.
I wonder if that rocket scientist is also now pursuing a career as an “ evolutionary historian ”. You get paid to write about science without needing to have the brains needed to actually do science.
https://en.wikipedia.org/wiki/O._J._Simpson_murder_case#Reaction_to_the_verdict
I believe that (and similar numbers for other species) is only based on SNPs and is still roughly correct. This 2006 article talks about how CNVs add to those differences.
https://genetics.thetech.org/original_news/news38
Then there are indels (insertions and deletions). I don’t know of a better number though and don’t have time to search now.
https://www.kidney.org/atoz/content/race-and-egfr-what-controversy
Instead we should just do it by training AI on whole genomes.
i'm going to get the language wrong, but there's that whole thing how the variations of a single gene don't tell races apart but that specific patterns of differences across the genome do.
That means that you don't have to have your treatment be a function of (alelle, race, sub-race, area of origin).
Instead just train an AI on the data from your trial on (efficacy, full genome) and then you can base your decisions on the full genome of the patient instead. (race, sub-race, area of origin) are encoded in the DNA in both cases but it'll be entirely opaque to us. That way it's not racist.
(of course the whole "all AI is racist" is already a thing so maybe it wouldn't help after all )Replies: @ic1000, @res
It’s actually not that simple. Systematic genetic variation which correlates with other attributes (e.g. environment) is a problem for GWAS. They go to great efforts to correct for population stratification (and probably throw out some useful signal along with the noise). This is part of the (probably primary) reason GWAS are so uniform population wise.
Strongly agree with your first paragraph. I wonder if these people realize how inconsistent that is.
If anyone is unaware of what he means by his last sentence, the site is sci-hub, which I believe is now hosted at sci-hub.se. It is a free index of a ton of academic papers that you normally could not access without paying Elsevier or some other company a ridiculous amount per paper, 20 bucks or so for a 3 page paper (none of that 20 bucks goes to the author or reviewers, of course…) As you could have probably guessed, it is hosted in Kazakstan, out of the reach of the lawyers.
Of course as with anything like this there is a degree of dodginess; don’t let it install anything on your computer, obviously. But if you want to freely access the scientific literature, well, the Kazakhs believe you should be able to.
“Erectus Walks Amongst Us” can be read right here on The Unz. If you’re curious why the “we’re all 99% the same” statement is false, read it.
Of course as with anything like this there is a degree of dodginess; don't let it install anything on your computer, obviously. But if you want to freely access the scientific literature, well, the Kazakhs believe you should be able to.Replies: @SimpleSong
Also a legal but less convenient method is to go to researchgate.net, which is sort of a pseudo facebook for academia, find the researcher who wrote the paper, and ask them to send you a copy. I’ve never had somebody refuse but you have to wait for them to respond. Anyway never pay the 20 bucks…
Yes. Another example is the treatment of congestive heart failure. The drug BiDil (a combination of two common medications in a fixed proportion) doesn't improve outcomes for white patients but does for African-American patients (compared to the standard of care).
Here is a 2017 anti-BiDil article based on messaging from the woke ProPublica collective. You have to scroll to the third-to-last paragraph for the grudging admission that it saves lives:Tellingly, that's immediately followed byThe most recent interesting update I could find is also from 2017, Clinical Effectiveness of Hydralazine-Isosorbide Dinitrate [BiDil] in African-American Patients With Heart Failure.Details: VA physicians looked at the records of 5,200 African-Americans with severe heart failure. Adjusted mortality at 18 months was 22.1% for BiDil patients, versus 25.2% receiving the non-BiDil standard of care (p = 0.009). The adjusted hazard ratio: 0.85 (95% confidence interval: 0.73 to 1.00). So BiDil was modestly effective in this cohort of very sick heart patients.Replies: @James N. Kennett
In the first wave of COVID in the UK, black and South Asian minorities were much more likely to die than whites. All sorts of reasons were proposed, including relative poverty and overcrowded living. This was not credible because the increased mortality also occurred among hospital doctors. It was a taboo to suggest that genetics had anything to do with it, because we all know that genetic differences only alter skin colour, and the colour and texture of hair.
Now scientists have proposed that blood group is a factor that makes COVID more infectious to certain minorities. This belief is acceptable to the Woke – as long as you don’t mention that blood group is determined by genetics.
Woke beliefs cost lives – minority lives. Do black lives matter to the Woke? Apparently not.
AFAIK covid is most dangerous to people with blood type A, which has highest prevalence among white people. And it is least dangerous to people with type O, which has highest prevalence among black people (in the US, anyway). But the differences among races aren't that high. say +/- 10 percentage points.
(see eg:
https://www.usnews.com/news/health-news/articles/2021-03-03/scientists-discover-why-blood-type-may-matter-for-covid-infection
and
https://www.news-medical.net/news/20210121/Blood-group-associated-with-cardiovascular-events-in-COVID-19-patients.aspx )
That said, how actionable is this info anyway? Would the response and prevention be different because blood type a vs type O have a 10% higher change of getting covid ( and something like 50% higher chance of needing ventilation once they have serious covid) ? (1)
1) studies linked from https://www.hematology.org/newsroom/press-releases/2020/possible-link-between-blood-type-and-covid-19
Race doesn't exist, but "ethnicity" will actually bump you up the "vulnerability" rankings for a covid jab in the UK.
https://digital.nhs.uk/coronavirus/risk-assessment
Click on "List of QCovid® risk factors in approximate order of weighting"
In descending risk order.
Ethnicity: Black African
Ethnicity: Caribbean
Ethnicity: Other ethnic group
Ethnicity: Other Asian
Ethnicity: Indian
Ethnicity: Bangladeshi
Ethnicity: Pakistani
Ethnicity: Chinese
Whites seem to be the control group. The one huge, glaring gap in the risk factors is sex - men are much more vulnerable than women, but a decision seems to have been taken to ignore that.
Odd thing is that covid doesn't seem to be rampant in black Africa, but then the population is pretty young.
It’s pretty obvious that they ultimately want to reduce the bulk of humanity genetically down to the lowest common denominator.
Orwell had something to say about ‘the Low’ in his most famous book. I’ve emboldened some particularly pertinent points:
From the same source as above (1984), a pretty good description of how the self declared ‘Woke’ look upon those they’ve ‘canceled’, and more or less everyone else besides who isn’t one of them…
99.9% is the classic pinko stat for anything they like. If it’s instead a really tiny figure they want to signal-boost, they multiply it by 10, e.g. “1 in 10 people are homosexual,” “3 out of 5 women have been sexually assaulted,” “50% of children live in food deserts”
Humans/great apes share the majority of hox genes of a housefly, does that mean we’re “almost identical” to them? Serious question, I’m trying to find out the Party’s position this week
https://twitter.com/disclosetv/status/1367528571380637697Replies: @AndrewR, @Anonymous, @Abolish_public_education, @Hypnotoad666, @guest007
The bias (racism) of graphing a comparison between LT debt and GDP is that it presumes there is some temperate zone for the two. In fact, the former should always be zero.
The bias of using GDP is that the intrinsically dubious figure includes government spending. Such spending is economically destructive. It’s racist to suggest otherwise.
The bias of plotting the two (ordinates) on a linear scale is that it gives the illusion that both growth rates are higher now than they’ve ever been, i.e. the inflective blowups. In fact, they’re both exponentials. That racism is compounded by the implication that things were better before (e.g. when the US was more white).
Of concern, the US’ economic growth rate has been under attack, by government interventions, for generations. Despite its amazing resilience, at some point it doesn’t bounce back (the real flattening of the curve).
We know that a SINGLE neucleotide difference in the DNA of a human can cause death, albinism, dwarfism, blindness, deafness, or any number of horrible genetic diseases, such as Sickle Cell Anemia.
Yet, these ignorant SJW and media whores tell us that the ~ 3,000,000 nucleotide differences in the average person is meaningless???? Lying, deceiving, Marxist all of them.
Note also that the 3,000,000 base differences are not distributed randomly across the thousands of different human populations, nor the ?dozen? or so living major human races. Because of hundreds or thousands of years of isolated inbreeding, each population/race has evolved its own unique set if genetic differences, shared only among that single population. It’s the UNIQUE COMBINATION of genes that give each race their particular combination of traits.
Same in the card game poker: it’s not that you hold a 10 of spades, its the particular COMBINATION of cards that gives you a winning or losing hand — for example, a 7, 8, 9, 10, jack straight — or four 10’s.
You are racist if you try to collect DNA from POC.
You are racist if you DON’T collect DNA from POC.
Remember, it’s actually NOT about fairness or racism. It’s about envy, shame, greed, and racial hatred, marketed as “equality” and “stop the hate”.
At the population level, the promise of “precision medicine” is never going to be realized. Hint: it’s more of a sooth-saying narrative to justify larger NIH budgets, a narrative pushed by academic medical centers and prominent individual scientists looking for large grants for hypothesis-free fishing expeditions.
Medical research scientists like the prestige and alleged nobility of their profession but couldn’t care a less about patients. Hell, they couldn’t care a less about anything or anyone but themselves. See the fate of James D. Watson and the NIH’s recently declared forever war against white accomplishment. Aside: where have I heard that lust for forever wars expressed before?
Just think what medical research in Trisomy 21 did for patients! As if anyone with that disease (Down Syndrome) could ever give informed consent. Some academic medical center somewhere made a ton of money developing a test to enable the extermination of that patient group. Maybe a genetic test for crime-think sympathies is just around the corner.
Mate selection and lifestyle choices made by me in my lifetime, by my parents on my behalf during their lives prior to my conception (especially) and after, and by my parents’ ancestors, are overwhelming going to determine my fate, not ex post facto “personalized” genetic tinkering or pharmacological fine tuning. Said “personalized” interventions will only be justifiable for corner cases and likely only affordable for the ultra rich.
Oh yes, there will be some spectacular successes, and not to trivialize their importance for the individuals involved. But at the population level? No, sorry, evolution and natural selection decide biological fate at the population level, not the self-serving fantasies of deluded scientists and gullible politicians.
Reducing your disease risk isn’t rocket surgery. To the extent that you can, most people just need to:
eat less
have a healthier diet
stop smoking
limit your drinking
avoid driving
get more fresh air
exercise more
get a good night’s sleep each night (avoid shift work)
have offline hobbies and interests
find more enjoyment (yes!) out of meaningful inter-personal relations
All just common sense from Grandma. All the MDs and PhDs in the world aren’t going to save me from my ancestors’ choices and my own lack of self-discipline and other stupid choices.
we do not really share 99% of our DNA with chimpanzees…yet they have 2 more chromosomes than Humans and there are numerous other important differences between Human and chimp DNA. The human genome has 3 billion base pairs while the Chimpanzee genome has 1.9 billion base pairs, so while we have 2 less chromosomes we have 1.1 billion extra base pairs compared to chimps.
In early works, divergence of human and chimpanzee genomes was estimated as roughly 1%. This estimate was based on the comparison of protein-coding sequences and didn’t consider non-coding (major) part of DNA. However, the idea of ~ 99% similarity of genomes persisted for a long time, until 2005 when nearly complete initial sequencing results of both human and chimpanzee genomes became available. It was found that genome differences represented by single nucleotide alterations formed 1.23% of human DNA, whereas larger deletions and insertions constituted an additional~ 3% of our genome. Moreover, even higher proportion was shaped by chromosomal inversions and translocations comprising several megabase-long chromosomal regions or even entire chromosomes, as for the chromosomal fusion that took place when the human chromosome 2 was formed. https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-020-06962-8
Although we may share 96% of our gene coding DNA, scientists are discovering that the non-coding DNA is important in Gene regulation and brain development. The 96% figure ignores most of our DNA differences, because most of our DNA is non-coding DNA and considered “Junk” DNA. But every year they discover more ways this junk DNA effects gene expression. To suggest that we share 96% of our DNA is misleading since we actually share less than 80% of our DNA with chimps if you include the non-coding DNA.
Humans 96 Percent the Same, Gene Study Finds. https://www.nationalgeographic.com/science/article/chimps-humans-96-percent-the-same-gene-study-finds
Noncoding regions of our genome may be key to how our brains develop
https://www.scientificamerican.com/article/is-junk-dna-what-makes-humans-unique/
I’d have said each person has a unique DNA, although the building blocks shared by each are the same (four nucleotides A, C, G, T)
Some bright person here can explain how the “All humans have the same DNA” claim is any different than this…
I ask for understanding, not snark.
The story of Henrietta Lacks is interesting, but doesn’t, IMO, rise to the level of an injustice.
Was her life damaged by culturing her cancer cells? Was the quality of care damaged?
It’s the equivalent harm of someone taking my hair clippings and making fake mustaches out of them. I wasn’t going to do anything with it anyways, so go ahead.
You have it and they don't. They want what you and your ancestors built -- things that they could never build themselves. They are unhappy, although they are blessed by living in super-rich America. They live much, much better here than their people live back in Africa, Middle East, or Central America. Yet, they do not recognize nor appreciate this.
Note also that millions of White Americans were willing to sacrifice for the betterment of our society -- fighting and dying in wars, volunteering for medical research, giving to charities, adopting minority children, building houses for the poor, giving taxes to support welfare, etc. Yet Black people generally refuse to tip, donate, adopt Black children, or as with the Lacks family, donate cells for research.
I remember how I learned about poor Henrietta Lacks. Someone was describing for me, with great enthusiasm, the then-recent book about Ms Lacks. And as I'm listening to my friend talk about the alleged injustice of it all, I'm thinking, Yeah, so what's the problem?
HeLa cells turned out to contaminate and displace other cell lines after even minor violations of sterile technique. At one point, quite a few standardized cultures used in cancer research were fount to be HeLa cells.
They need to get some respected black celebrities like Ice Cube and Joy Ann Reed to do some PSA’s along the lines of, “You know they don’t want you to donate DNA. Fight white supremacy. Donate!”
The .1% difference is in the coding genes, not the non-coding DNA. Only 2% of our DNA codes for a protein, the other 98% was once considered junk DNA, yet the junk DNA does influence our genes. We also consider the coding gene to be identical even if one person has two copies of the gene code and another person has 3 or 5 copies. Yet sometimes this makes a real difference in ones phenotype. Having two copies of one Specific gene found only among Europeans offers protection from HIV infection, while having three copies of chromosome 21 causes Down’s syndrome. There are multiple examples of good and bad effects of having multiple copies of a gene.
Was her life damaged by culturing her cancer cells? Was the quality of care damaged?
It's the equivalent harm of someone taking my hair clippings and making fake mustaches out of them. I wasn't going to do anything with it anyways, so go ahead.Replies: @Patriot, @International Jew, @Anonymous
Again, it’s not about fairness, it’s about envy, shame, greed, and racial hatred.
You have it and they don’t. They want what you and your ancestors built — things that they could never build themselves. They are unhappy, although they are blessed by living in super-rich America. They live much, much better here than their people live back in Africa, Middle East, or Central America. Yet, they do not recognize nor appreciate this.
Note also that millions of White Americans were willing to sacrifice for the betterment of our society — fighting and dying in wars, volunteering for medical research, giving to charities, adopting minority children, building houses for the poor, giving taxes to support welfare, etc. Yet Black people generally refuse to tip, donate, adopt Black children, or as with the Lacks family, donate cells for research.
The whole “Africa is most genetically diverse” is typically a bait and switch anyway. It relies on using the Khoisan (aka Bushmen), who were hunted to near extinction by the Bantu and are in the margins of deserts in South Africa, pygmies and Hottentots (also hunted to near extinction and relegated to rainforests), and Arabs in the Mediterranean. Sub-saharan Africa does not seem to be varied that much aside from those marginalized peoples.
There are four basic language groups in Africa, but while linguistically they differ a lot, the research I’ve seen suggests they aren’t that different in DNA–people in the Bantu/Congo language group are not a lot different genetically from the Afro-Asiatic group (i.e., Yorubas and Hausas are not that different despite the different language groupings), nor is the Nilo-Saharan genetically (i.e., the Kanuri, a stone’s throw from the Hausa).
East Africans must have had some intermixing with Mediterranean/Arabic groups given their features (smaller noses, lighter skin), but in other genetic measures they are more like West Africans than, say, East or Southeast Asians.
It's the thrust of the "whether you like it or not" at the end that's interesting. You don't think that folks can "look past" the skin and the flesh to see the spirit or the joy a person is?Replies: @Bardon Kaldian
It is not about individuals. It is about the trivial fact that human beings live in collectives, that these collectives differ, and that, statistically, men & women like to live among those who are like them. And “like them” on the most basic level means race. Sometimes, religion may seem to be of primary importance, or perhaps, language, or national culture. But, these are simply combined with other traits.
A person can, of course, go beyond racial stuff; beyond material; beyond collective etc., but it is very rare & of virtually no importance re most human beings’ behavior or aspirations. It is as true now as it had been 2400 years ago when Aristotle wrote that man is a social being, and when Herodotus (or some similar guy) said that “we Hellenes have common ancestry, language, gods and way of life that distinguishes us from others”.
Spiritually, St.Paul has noted that while we all have image of God (or any other similar thing), down here our lives are regulated by differences (men, women, slaves, ..); in another spiritual climate, Hinduism, virtually no one questions that all humans are Atman embodied, jiva- but there are laws galore about castes, (im)purity etc. etc.
So, when it comes to ordinary life of most people everywhere, Nicholas Earp was right (although he was talking only about family- a people is essentially an extended family):
The blood type data suggests it’s actually more dangerous for white people on average:
AFAIK covid is most dangerous to people with blood type A, which has highest prevalence among white people. And it is least dangerous to people with type O, which has highest prevalence among black people (in the US, anyway). But the differences among races aren’t that high. say +/- 10 percentage points.
(see eg:
https://www.usnews.com/news/health-news/articles/2021-03-03/scientists-discover-why-blood-type-may-matter-for-covid-infection
and
https://www.news-medical.net/news/20210121/Blood-group-associated-with-cardiovascular-events-in-COVID-19-patients.aspx )
That said, how actionable is this info anyway? Would the response and prevention be different because blood type a vs type O have a 10% higher change of getting covid ( and something like 50% higher chance of needing ventilation once they have serious covid) ? (1)
1) studies linked from https://www.hematology.org/newsroom/press-releases/2020/possible-link-between-blood-type-and-covid-19
I wonder if that rocket scientist is also now pursuing a career as an “ evolutionary historian ”. You get paid to write about science without needing to have the brains needed to actually do science.Replies: @Barnard
Read the “reaction to the verdict” section of the Wikipedia page for the O.J. trial. I didn’t realize so many more blacks now admitted Simpson is guilty. What a terrible job the prosecution did with the jury selection.
https://en.wikipedia.org/wiki/O._J._Simpson_murder_case#Reaction_to_the_verdict
“All sorts of reasons were proposed, including relative poverty and overcrowded living. This was not credible because the increased mortality also occurred among hospital doctors.”
Race doesn’t exist, but “ethnicity” will actually bump you up the “vulnerability” rankings for a covid jab in the UK.
https://digital.nhs.uk/coronavirus/risk-assessment
Click on “List of QCovid® risk factors in approximate order of weighting”
In descending risk order.
Ethnicity: Black African
Ethnicity: Caribbean
Ethnicity: Other ethnic group
Ethnicity: Other Asian
Ethnicity: Indian
Ethnicity: Bangladeshi
Ethnicity: Pakistani
Ethnicity: Chinese
Whites seem to be the control group. The one huge, glaring gap in the risk factors is sex – men are much more vulnerable than women, but a decision seems to have been taken to ignore that.
Odd thing is that covid doesn’t seem to be rampant in black Africa, but then the population is pretty young.
blacks don’t volunteer sh**.
start handing out cash, malt liquor, or fried chicken for cheek swabs at corner 7-11s and you’ll get all the black DNA you need.
then again, the fellas know DNA is a good way to end up locked up, so it may be a tough sell, even with the chicken.
https://twitter.com/disclosetv/status/1367528571380637697Replies: @AndrewR, @Anonymous, @Abolish_public_education, @Hypnotoad666, @guest007
Actually, Mr. Aziz should maybe show a chart that labels its y axis. His chart is apparently the annual budget deficit as a percentage of GDP (and cuts off at 2015 for some reason). The original chart is total accumulated debt as a % of GDP, which is a totally different thing.
Organ donation is racist. I can think of a way to solve that problem.
https://unos.org/news/racial-equity-in-transplantation/
All this debt and most people have only seen a couple grand tops in NEETbux.Replies: @guest007
Look up how much paper money actually exist in the U.S. before using the very tired, very old, very anachronistic cliché. If a government wants to expand the money supply, all it does is make bookkeeping entries.
https://twitter.com/disclosetv/status/1367528571380637697Replies: @AndrewR, @Anonymous, @Abolish_public_education, @Hypnotoad666, @guest007
The actual national debt is around $21 trillion since the rest of the debt is just one part of the government owing another part of the government money.
Thank you.
Alternate expression: Grammar racist.
At 30 months of age your baby is racist….the state must intervene and correct this white racist behavior…so says the Arizona Department of Education:
https://www.azfamily.com/news/arizona_schools/arizona-department-of-education-website-suggests-talking-to-your-infant-about-race/article_43821a10-7ca1-11eb-9cef-370e22b8b51e.html
White rape victims may be a good place obtain negro DNA.
Graduation schedule at Columbia:
What? No whites are graduating?
Virtual Ceremony ScheduleCeremonies are listed chronologically.
Native Graduation: Sunday, April 25 at 4:00 p.m. EDT
Lavender Graduation (LGBTQIA+ community): Monday, April 26 at 4:00 p.m. EDT
Asian Graduation: Tuesday, April 27 at 10:00 a.m. EDT
FLI Graduation (First-generation and/or low income community): Tuesday, April 27 at 7:00 p.m. EDT
Latinx Graduation: Thursday, April 29 at 6:00 p.m. EDT
Black Graduation: Friday, April 30 at 4:00 p.m. EDT
https://www.cc-seas.columbia.edu/multicultural/graduateregistration
I understand that multitude of descendants want some cash because of this supposed great injustice. But should the researchers have just foregone the use of this cell line? It may have great value to medical science but a few microscopic cancer cells were really of no value to Lacks because there was no market to sell them. By the way, the cells were obtained in the course of Lacks' treatment for cancer at some place called Johns Hopkins.Replies: @AndrewR
Jesus Christ. I’m as racist as they come, but your comment is crude and petty. Show her some respect. She’s done way more for science than you have, I’m sure.
There, by the way, is the answer to the shortage of minorities volunteering their DNA.
"Why is genetic research so white and what do we do about it?"
Er... start your own research and ask people to donate?Replies: @Bardon Kaldian, @Templar
Nope:
Where an individual is arrested for, but not charged with, a qualifying offence, their DNA profile and fingerprint record will normally be deleted. However, the police can apply to the Biometrics Commissioner for permission to retain their DNA profile and fingerprint record for a period of up to 3 years.4 Apr 2013
http://www.gov.uk › publications › protec…
Protection of Freedoms Act
What’s that BS about gran’ma be racist?! – White supremacy, duh.
Dude….David “Mr.” French or Jonah Goldberg are totally going to accuse you on Twitter of having claimed that all individual Blacks look alike. They probably already have. Intelligent people can see what you meant, but charlatans going to, uh…charl?
I’ve pointed out to my wife that she shares more DNA with a female Bonobo than with me.
I have only done this once.
A secondary question is why don't the highly educated Asians who live in the U.S. act more like middle class whites when it comes to healthcare?Replies: @Bill Jones, @3g4me
Because they want to continue to live longer than Whites?
Just a guess.
I really don’t think we have to worry about black people having too LITTLE self-esteem.
‘…but apparently are ok with the government forcibly making a DNA database of any unfortunate soul that a pig might happen to arrest for any reason.’
We could restrict the police to taking DNA only from black suspects. Would that make it all better?
What is an evolutionary historian, anyway?
Steve Sailer Retweeted:
Was her life damaged by culturing her cancer cells? Was the quality of care damaged?
It's the equivalent harm of someone taking my hair clippings and making fake mustaches out of them. I wasn't going to do anything with it anyways, so go ahead.Replies: @Patriot, @International Jew, @Anonymous
Having way more than you need of something is the defining feature of cancer.
I remember how I learned about poor Henrietta Lacks. Someone was describing for me, with great enthusiasm, the then-recent book about Ms Lacks. And as I’m listening to my friend talk about the alleged injustice of it all, I’m thinking, Yeah, so what’s the problem?
Lmao yes I know they’re not just printing and minting more bills and coins. I was referencing a popular meme that I doubt anyone takes literally
Universal genetic analysis would disclose the true reason for both negro intellectual underachievement and negro criminal-violence overachievement. It is, therefore, intolerable.
The egalitarians see the tide of science coming in to wash away their delusions, and they’re terrified.
A secondary question is why don't the highly educated Asians who live in the U.S. act more like middle class whites when it comes to healthcare?Replies: @Bill Jones, @3g4me
@50 Guest007: “A secondary question is why don’t the highly educated Asians who live in the U.S. act more like middle class whites when it comes to healthcare?”
Answer: Because there’s no such thing as magic dirt, you fool. They’re not Whites with yellow skin. They are a separate and alien race. Their history and genetics (which together create culture) are utterly different from that of White Europeans, and they remain different regardless of where they are born or raised (or profit at the expense of the locals). They will not donate anything of their own nor risk anyone of their own kind unless it’s for the benefit of themselves (and even then it’s questionable). They have no concept of the common good nor care for society as a whole – their sole concern is how well they and their immediate family fare. Once excellent visual example as how their interior home may be spotless and elegant, while their street (or neighborhood, or overall city) may well be like a sewer. Sh*tholes are made, not born, by people genetically predisposed to low trust and high ethnocentrism.
What did I say specifically that hurt your feelings?
One would be surprised how memes affect peoples thinking. There is only around $2 trillion in circulation with a lot of it being outside the U.S.
Just a guess.Replies: @guest007
But Asians in the U.S. actually live longer than if they stayed in their original country. Also, Asian-Americans should be more willing to donate organs, donate their bodies to sciences, participate in drug trials and medical research, and volunteer for protocols.
There you go. You are now getting properly Woke.
The prices don’t seem ridiculously high, albeit not as reasonable as my local Olive Garden. And at my Olive Garden there’s indoor seating which poses less risk than being out in the open where some bandits can force me to surrender my Richard Mille watch.Replies: @Muggles, @Rob
If you wear a half million dollar watch in public you may as well be wearing a suit made of real $100 bills.
Or a large sign that says “rob me, I have a half a million in jewelry on me.”
I don’t mind rich people. Rich and stupid, yes.
I have only done this once.Replies: @Muggles
So I take it she no longer wants you to share your DNA with her.
See Andrew? Now you’ve tangled with a real autist.
Was her life damaged by culturing her cancer cells? Was the quality of care damaged?
It's the equivalent harm of someone taking my hair clippings and making fake mustaches out of them. I wasn't going to do anything with it anyways, so go ahead.Replies: @Patriot, @International Jew, @Anonymous
it hasn’t been all gold. Henrietta Lacks’ cancer cells turn out to be quite aggressive.
https://journals.sagepub.com/doi/abs/10.1177/1933719114522518
HeLa cells turned out to contaminate and displace other cell lines after even minor violations of sterile technique. At one point, quite a few standardized cultures used in cancer research were fount to be HeLa cells.
The prices don’t seem ridiculously high, albeit not as reasonable as my local Olive Garden. And at my Olive Garden there’s indoor seating which poses less risk than being out in the open where some bandits can force me to surrender my Richard Mille watch.Replies: @Muggles, @Rob
A hot 0.5 megadollar watch is not quite a white elephant, because it does not require upkeep.
No one will pay retail for a stolen watch. Everyone who is the target market for them knows that a watch was stolen, so when a shady guy is offering one, just one, he does not have an inventory, you can be pretty sure it is the stolen one. Not to mention, the skells that stole it probably do not know anyone with even tens of thousands of dollars to spend on a fancy watch. It kinda seemed like there were a lot of black celebs there. Is it a place popular with blacks?
The fact that there is a market for luxury items that expensive is proof we need wealth redistribution. Extremely unequal societies seem to end end up with sterile consumption of wealth in luxury items that rich people use to signal to other rich people that they are rich people. It seems to be a failure mode caused by extreme inequality.
To stay on iSteve themes, a chunk of inequality is caused by immigration lowering wages and raising rents and home prices (price of bread goes up: inflation price of a home goes up:wealth)
Just as 1984 had a 'dual system of astronomy' Woke 'science' has a dual system of race. [It's a bit like the proverbial shady business which maintains two sets of account ledgers, ie a public one with false numbers for the stockholders to see, and a second hidden account ledger containing the true numbers for the director's use.]
As helpfully expounded upon by O'Brien when torturing Winston:Replies: @FLgeezer
>Just as 1984 had a ‘dual system of astronomy’ Woke ‘science’ has a dual system of race.
https://www.local10.com/news/local/2021/03/06/miami-native-playing-big-role-in-nasas-historic-mission-to-mars/
More “dual system of astronomy” (LOL!):
“Touchdown Site Named
With Perseverance departing from its touchdown site, mission team scientists have memorialized the spot, informally naming it for the late science fiction author Octavia E. Butler. The groundbreaking author and Pasadena, California, native was the first African American woman to win both the Hugo Award and Nebula Award, and she was the first science fiction writer honored with a MacArthur Fellowship. The location where Perseverance began its mission on Mars now bears the name “Octavia E. Butler Landing.”
https://www.nasa.gov/press-release/nasa-s-perseverance-drives-on-mars-terrain-for-first-time
Right, if you think the millions of Third Worlders saved by Western medical breakthroughs somehow benefited white people. Not to mention the obese, diabetic walking dumpsters in the ‘hood being kept alive by wypipo jewjew.
The world’s most beautiful woman is spoken for:
The squandering of MacKenzie’s beauty will continue:
I think of all the organizations and people I hear on public radio and how operationally, their aim in life is to grab someone else money, or even worst, to create a never ending stream of funds siphoned off the taxpayer so as to enrich themselves and every lefty "progressive" they can find.
Monster NGOs is the name of the game for these people pushing "The Giving Pledge."
Which of course they'll run.
https://twitter.com/WSJ/status/1368679130204696579
The squandering of MacKenzie's beauty will continue:
https://twitter.com/teddyschleifer/status/1368679315823497216
https://twitter.com/TimOBrien/status/1368697232262856709Replies: @Joe Stalin
I am always amazed at the number of wealthy people that have been talked into doing this.
I think of all the organizations and people I hear on public radio and how operationally, their aim in life is to grab someone else money, or even worst, to create a never ending stream of funds siphoned off the taxpayer so as to enrich themselves and every lefty “progressive” they can find.
Monster NGOs is the name of the game for these people pushing “The Giving Pledge.”
Which of course they’ll run.