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ASHG 2014
• September 11, 2014
• 2 CommentsQ&A
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Dienekes has posted some abstracts. I’ll be there.

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  1. Walter Sobchak says: • Website
    September 11, 2014 at 4:03 pm GMT • 200 Words

    Razib: I would appreciate your comments on this article:

    “Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins” by Carmi, Hui, Kochav, et.al. in Nature Communications 5,
    Article number: 4835, doi:10.1038/ncomms5835 Received 24 June 2014, Accepted 28 July 2014, Published 09 September 2014
    http://www.nature.com/ncomms/2014/140909/ncomms5835/full/ncomms5835.html

    Abstract: The Ashkenazi Jewish (AJ) population is a genetic isolate close to European and Middle Eastern groups, with genetic diversity patterns conducive to disease mapping. Here we report high-depth sequencing of 128 complete genomes of AJ controls. Compared with European samples, our AJ panel has 47% more novel variants per genome and is eightfold more effective at filtering benign variants out of AJ clinical genomes. Our panel improves imputation accuracy for AJ SNP arrays by 28%, and covers at least one haplotype in ≈67% of any AJ genome with long, identical-by-descent segments. Reconstruction of recent AJ history from such segments confirms a recent bottleneck of merely ≈350 individuals. Modelling of ancient histories for AJ and European populations using their joint allele frequency spectrum determines AJ to be an even admixture of European and likely Middle Eastern origins. We date the split between the two ancestral populations to ≈12–25 Kyr, suggesting a predominantly Near Eastern source for the repopulation of Europe after the Last Glacial Maximum.

  2. ohwilleke says: • Website
    September 11, 2014 at 5:49 pm GMT

    I reckon that you’re on the winning side of this comparison.

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