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From NPR:

Gene-Edited ‘Supercells’ Make Progress In Fight Against Sickle Cell Disease
November 19, 20197:01 AM ET

ROB STEIN

Doctors are reporting the first evidence that genetically edited cells could offer a safe way to treat sickle cell disease, a devastating, incurable disorder that afflicts millions of people around the world.

Billions of cells that were genetically modified with the powerful gene-editing technique called CRISPR have started working, as doctors had hoped, inside the body of the first sickle cell patient to receive the experimental treatment, according to highly anticipated data released Tuesday.

The edited cells are producing a crucial protein at levels that have already exceeded what doctors thought would be needed to alleviate the excruciating, life-threatening complications of the genetic blood disorder, the early data show. Moreover, the cells appear to have already started to spare the patient from the agonizing attacks of pain that are the hallmark of the disorder.

“We are very, very excited,” says Dr. Haydar Frangoul of the Sarah Cannon Research Institute in Nashville, Tenn., who is treating the patient. “This preliminary data shows for the first time that gene editing has actually helped a patient with sickle cell disease. This is definitely a huge deal.”

Frangoul and other researchers caution, however, that the results involve just one patient who was only recently treated. It is far too soon to answer the most crucial questions: Will the modified-cell treatment continue to improve the patient’s health? Will the treatment keep working? Will it help her live longer? Is it safe in the long term?

“We are hoping it is” a success, Frangoul says. But “it is still too early to celebrate.”

NPR has exclusive access to chronicle the experience of Frangoul’s patient, Victoria Gray of Forest, Miss., the first person with a genetic disease to be treated with CRISPR in the United States.

Sickle cell anemia is one of the first genetic diseases to be well understood. Linus Pauling et al figured it out in 1949. It’s a recent mutation that probably arose around the time West Africans started agriculture a few thousand years ago. Chopping down forests exposed farmers to the anopheles mosquito that likes to breed in sunny puddles. At some point, the malaria carried by the mosquito became able to afflict humans, with devastating impact.

In response, the sickle cell mutation arose, but, tragically it is nature’s Quick and Dirty Darwinian response: if you inherit one copy your chance of dying of falciparum malaria declines, but if you inherit two copies, you will likely die painfully in early childhood without intensive medical care. Since falciparum malaria is rare in the United States, the mutation serves little purpose here and inflicts much suffering.

But a lot of genetically-driven aspects of human life aren’t well-conceptualized by the lessons of sickle cell. If you aren’t as smart as you think you’d like to be, you probably can’t influence your IQ noticeably by changing one mediocre gene into one great gene. Cognitive skills are just too influenced by thousands of genes.

On the other hand, what if you had one negative mutation? Could that drive down your IQ notably and could it be fixed by this type of technology?

 
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  1. If memory serves, the great Tupac Shakur once dissed a rival, Prodigy (of the rap duo Mobb Deep) about his sickle cell. So if they cure it, diss tracks in general may be forever changed. Therefore I cannot support this research.

    • Replies: @Kronos
    , @Hail
  2. songbird says:

    I think health definitely effects how smart you are – ie. if you are in chronic pain, it will probably lower your natural IQ and productivity. Not to mention, that sickness can have a socially isolating effect and that, in itself, is unhealthy, and might effect one’s mental abilities.

  3. utu says:

    “In response, the sickle cell mutation arose, but, tragically it is nature’s Quick and Dirty Darwinian response:” – Misleading and inaccurate. There was no response. The mutation was selected but not caused by malaria. The mutation most like existed before the first spread of malaria. Furthermore this proces should not be called as Darwinian response. The process is passive. Some people have higher death rate than other. That’s all.

    • Replies: @Anonymous
  4. Moses says:

    Sickle cell cure today, a new race of Genetic Chinese Supermen tomorrow!

  5. “Gene-Edited ‘Supercells’ Make Progress In Fight Against Sickle Cell Disease”

    Just what the world needs, more negroes. Time to make an adjustment to the most important graph in the world.

    • Agree: BB753, EldnahYm
  6. You may want to find out if the cells are modified red blood cells only. Don’t red blood cells die in about 70 days? If so won’t the patient need periodic infusion with fresh red blood cells? I believe that RBC have no nucleus as one more complication so can’t divide and grow. Maybe the fix is upstream and more permanent. Yuge in any case. Ok Boomer time for bed.

    • Replies: @Glaivester
    , @Anon
  7. Pongo says:

    There are Europeans with this disease, so it probably didn’t arise with Sub-Saharan Africans or in West Africa.
    It must have a common origin going on – Malaria was common in Southern Europe, and the best candidates are either the Early European Farmers, who migrated from Iberia to Africa or some deep ancestry, akin to the Anatolian Hunter Gatherers or Basal Eurasians who influenced the likes of the Iberomaurusians.
    Haplogroups E and R1b went from Eurasia to Africa. The R1b-V88 story is pretty much a mystery and ticks all the correct boxes.

    About Gene Editing: won’t be a good thing, morally or scientifically.
    There’s something called unintended consequences, and ‘science’ has proved that after decades of something being considered settled, it can be overturned, or have some disastrous consequences – think about how many times scientists were wrong, it boggles the mind.
    So, no: we don’t even know the effects of GMO, and now we want to become the GMO?

    • Replies: @Philip
  8. But a lot of genetically-driven aspects of human life aren’t well-conceptualized by the lessons of sickle cell. If you aren’t as smart as you think you’d like to be, you probably can’t influence your IQ noticeably by changing one mediocre gene into one great gene. Cognitive skills are just too influenced by thousands of genes.

    On the other hand, what if you had one negative mutation? Could that drive down your IQ notably and could it be fixed by this type of technology?

    While the many forms of stupidity are not living malarial parasites, it is an interesting comparison. Humans have been struggling with the consequences of recognition error for tens of millennia, so it makes sense that genetic markers for recognition intelligence would be numerous and well distributed. But as society becomes more complex, with greater opportunity for grifting, perhaps grifters develop new strategies that are immune from recognition by the current portfolio of inherited talent. In fact, some of these grifters have amassed enormous non-profit endowments, even surpassing $450 millions. New research to identify or develop genes to recognize these parasites would likely be welcomed with ovation by our media friends and neighbors.

  9. This seems like an interesting test case for Nassim Taleb’s emphasis on the alleged prevalence of extremely complex systems, unintended consequences, failed top-down pseudo-scientific engineering, etc.

  10. Read article. Duh. Bone marrow cells. Wow.

  11. Not Raul says:

    Perhaps embryos could be screened for major negative mutations.

  12. Because this involves blood cells this may be a special case as blood cells are easy to introduce back into the body where they are active. Still, a good sign of things to come.

    It would seem easy, but perhaps not worth it, to repair humanity’s defective vitamin C gene. Primates create their own vitamin C, but all homo sapiens carry a defective version of this gene.

  13. Kronos says:

    Another medical breakthrough in under three months? Wow!

  14. I could use that IQ upgrade. Is it done yet? Ok. I admit it. Yo soy Boomer pendeja.

    • Replies: @Kronos
  15. gcochran says:

    Sickle-cell itself decreases IQ: you get cerebral infarcts. Presumably Taleb knows all about that.

    It started in West Africa, about 7k years ago.

    • Replies: @prime noticer
  16. Anonymous[367] • Disclaimer says:

    Unintended Consequences???

    What about Sardinia, where it shows that after they killed all the mosquitoes with DEET in the 1940s, the lack of a malaria threat led to a scourge of autoimmune issues:

    “In the latest example of this finely balanced fight, new research reveals that a genetic mutation that increased resistance to malaria in one group of people also increased their rates of the autoimmune diseases of multiple sclerosis and lupus. Autoimmune diseases are conditions under which the immune system attacks the body’s own tissues.”

    https://www.livescience.com/58860-sardinia-mutation-fights-malaria-but-raises-autoimmune-disease-risk.html

    • Replies: @prime noticer
  17. There are Europeans with this disease, so it probably didn’t arise with Sub-Saharan Africans or in West Africa.

    It’s also known in central and southern India.

  18. “If you aren’t as smart as you think you’d like to be”

    Heh.

  19. Not Raul says:
    @Reg Cæsar

    It’s possible that Muslim rulers in India imported some black African slaves.

    This may have brought the disease to India.

    • Replies: @Reg Cæsar
  20. Anon[247] • Disclaimer says:

    If you aren’t as smart as you think you’d like to be, you probably can’t influence your IQ noticeably by changing one mediocre gene into one great gene. Cognitive skills are just too influenced by thousands of genes.

    Take the black children out of the Africa and they get Ph.D.’s in math prior to the age of 14. Her mother is also a mathematician.

    https://www-m.cnn.com/2015/03/09/africa/esther-okade-maths-genius/index.html?r=https%3A%2F%2Fduckduckgo.com%2F

    Meet the 10-year-old maths genius who’s just enrolled at college

    By Lauren Said-Moorhouse, for CNN

    Updated at 8:53 AM ET, Wed March 11, 2015

  21. A123 says:

    If you aren’t as smart as you think you’d like to be, you probably can’t influence your IQ noticeably by changing one mediocre gene into one great gene. Cognitive skills are just too influenced by thousands of genes.

    On the other hand, what if you had one negative mutation? Could that drive down your IQ notably and could it be fixed by this type of technology?

    For the next few generations — The risks of an error are high. What are the rewards?
    — If I had Cystic fibrosis (CF) it would be worth the risk to make sure my kids were CF gene free.
    — For a marginal improvement in multi-gene characteristics the cost + risk will keep essentially everyone away.

    The early adopters for safe tweaks are likely to be what many would consider vanity. Eye color. Hair color. A few inches of height for males within the normal human range (6′ 2″ vs. 5′ 10″).

    Long term you have to compete with Anatoly. Unless FTL turns up, humanity is ill constructed for multi-generational interstellar travel. Either:
    — Humanity will have to be gene edited for an entire low-G life including procreation.
    — Mind machines will have to take the years for us.

    PEACE 😇

  22. Anonymous[509] • Disclaimer says:

    Cognitive skills are just too influenced by thousands of genes.

    This accounts for the many human variations on what is called “high IQ”….. people are familiar with the math/science and reading/writing differences but there’s more to it.

    Manipulativeness (for lack of better word) is a form of intelligence. There are people out there who have nothing really going on upstairs but the ability to manipulate others. These people can go very far in life.

    The previous thread on changing demographics didn’t mention that swapping comparable IQ asians for whites will produce profound change in the society. IQ is complex.

    Changing demographics in hgh iq niches is not IQ driven I conclude. We see white male gentiles declining in top school enrollment and top job niches in modern America and yet there is no evidence within the huge data set known as the internet that white male gentiles are lagging other groups in intelligence. Along with the erosion of white male status in various niches out in the real world we should see a correlation on the internet. E.g white male gentiles should not be leaders on twitter or the blogosphere or anywhere else on the internet that requires high IQ output.

    • Replies: @nymom
    , @Jack D
  23. Anonymous[509] • Disclaimer says:

    IQ is very complex. Smart people who aren’t manipulators don’t respect the intelligence of master manipulators. That’s real bias. The greatest example of all time is Trump and his detractors.

    There are shallow manipulators out there doing world changing deeds. For example this daughter of Bruce Jenner and the Kardashian matriarch. I can’t even remember her fucking name but I did learn recently that she is the youngest self-made billionaire on planet earth!

    Now I’m sure that the Steveosphere would give her a low intelligence rating. Many smart people think shallow = stupid. But no the truth is that IQ is very very complex.

    • Replies: @donvonburg
  24. Anonymous[214] • Disclaimer says:

    Damn white male ‘racists’ at it again, making non-whites feel bad by achieving more in science and medicine.

  25. Anonymous[922] • Disclaimer says:

    Maybe the presence of one “negative mutation” shifts the type of IQ instead of driving the IQ down.

    Let’s say obviously Ron Unz has a high “perceptive” IQ. That’s what website unz.com shows. Perceptive intelligence. Not shallow.

    Also let’s say Don Unz (Ron’s brother with the negative mutation) has a high “deceptive” IQ and his website is Dailymail.co.uk. At first glance Don’s website appears shallow and low IQ. But closer inspection reveals it to be filled with sophisticated manipulative psy-ops.

    Maybe Ron and Don both think the other’s website is a complete waste of time. And the difference in their worldviews is just the one mutation.

  26. A cure for a painful disease suffered almost exclusively by blacks is cured by expensive, long-term research by almost exclusively white scientists, paid for by donations and tax funding pain almost entirely by whites.

    Somehow the story has to be spun so this is an example of structural racism hurting whites and benefiting blacks. This will require some imaginative re-working by the propaganda machine.

  27. Glaivester says: • Website
    @Global citizen

    Red blood cells contain no DNA and you could not really have a genetically-modified red blood cell – the cells would almost certainly be the stem cells that produce the red blood cells.

    • Replies: @Anon
  28. Kronos says:
    @Daniel Williams

    Do you think they’ll create an anti-obesity vaccine for Biggie Smalls?

    • Replies: @Lurker
  29. Kronos says:
    @Global citizen

    If you had to choose strictly between a verbal or visual-spatial bump bump which one would you choose?

    (I know that’s almost impossible because of the “G Factor” but please play along…)

  30. danand says:

    Dogs, not Africans, but still interesting. Did not know cancer was #1 killer of canines until this story hit the local news tonight. Maybe an effect from too much inbreeding; not enough diversity?

    • Replies: @Alden
  31. @MikeatMikedotMike

    Shouldn’t allow these mean spirited comments. It sounds too hateful.

  32. Good news!

    I wonder how Black people will thank White people for this medical breakthrough?

    You’re welcome.

  33. @Reg Cæsar

    Whoa, those dudes in the Horn of Africa did NOT like West Africans!

  34. Beware of CRISPR – it does not yet live up to the hype that it offers precise genome editing. We must watch out in case the huge investment in CRISPR pushes the technology into therapies before it is ready.

    https://www.alzforum.org/news/research-news/crispr-gene-editing-may-not-be-so-precise-after-all

  35. The efforts of the black panthers in fighting sickle-cell may finally be paying off.

  36. Philip says:
    @Pongo

    Incorrect. Thallesimia works in the same way (one copy good for coping with malaria, two bad health impacts) – but just as East African and European ability to process milk post weaning seems the same, they – and these two malaria tweaks – arose independently.

  37. @Reg Cæsar

    Always said Greece doesn’t belong in Europe.

  38. @Kronos

    If you had to choose strictly between a verbal or visual-spatial bump bump which one would you choose?

    Real Men will always choose V-S over verbal.

  39. Of course, the suffering caused by sickle cell anemia is dwarfed by the suffering caused by malaria. And we have the technology (DDT, etc.) to eliminate malaria by making the relevant mosquito species extinct (just as we did in the Southern U.S. states a century ago). But we can’t use that technology because the eco-Nazis prefer human suffering to the extinction of pernicious insect species, particularly when the humans doing the suffering are far away from them and theirs.

    • Replies: @Anonymous
  40. Lurker says:
    @Kronos

    I thought Tupac’s friends already did that?

    • LOL: Daniel Williams
    • Replies: @Kronos
  41. rodmunch says: • Website

    the fact that NPR (see steve’s previous post on reliable media) has first dibs is more worrying.

    • Agree: Jim Don Bob
  42. @Anonymous

    No, IQ is what it is, a defined set of tests. They correspond with success in the real world when deception, social engineering, salesmanship, nepotism, and those other things are taken out of the mix.

    Put a Gypsy in a machine shop and micromanage him so he either learns the trade and practices it honestly or he starves, and-he starves. He will never get stuff like making measurements with micrometers and calipers, setting up lathes and mills, laying out work, reading blueprints down even if he wanted to. He is , invariably, very dyslexic for one thing, and also he is going to be very disruptive in the shop environment. They will in the real world kick him out the door in a week or so. Yet he has a type of intelligence IQ tests don’t measure. He can size people up quickly, figure out what their vulnerabilities to being conned are, can work out scams on the fly honest people could not think out if their lives depended on it. Even in 2019 America he can go through life with multiple names and identities, scam his way into all sorts of situations-they once busted a Gypsy pulling a scam inside a nuclear weapons plant that was considered the securest facility in the continental US. He literally walked into the place with a badge he’d pilfered from someone in the (itself highly secure) parking lot. He walked and a couple of people got fired, they were too embarrassed to charge him in open court.

    Likewise Australian aborigines might have IQs in the 65 range but even as kids they can set out on foot across the outback and survive where only the most highly trained and well conditioned military commando types amongst whites would even have a chance-and probably beat the commando to where they are headed. They seem to instinctively know where “home” is. They easily avoid the very dangerous snakes and spiders Australia is famous for. It would be interesting to see how they’d do in a different but equally hostile environment, but probably hyenas, wolves or leopards would get them where feather-indians or African tribals would be okay.

    Success in Western civilization, if one excludes criminal or sports/entertainment performing, pretty well matches exactly with what the test Western civilization has invented for measuring probable success tests for. What a coincidence!

  43. Bruno says:

    It’s already the case with Phenylketonuria. Affected people had on average 20 IQ less than Down syndrome ones (35IQ). And it’s cured only by giving a special régime to kids when there brain is being built.

    Down syndrome could be fixed and probably people would avoid having an average IQ of 55 …

    There are quite a lot of bad single gene stuff …

  44. Anonymous[192] • Disclaimer says:
    @utu

    Yes, but the relative increase in frequency of that gene (caused by the relative die-off of those not carrying it) is what Steve refers to.

  45. ” Could that drive down your IQ notably and could it be fixed by this type of technology?”

    Sure,

    if they ever locate a gene or sequence of genes that impacts, controls or determines IQ.

    But the fact that the procedures in yielding more than expected is that warning sign in my view to go slow to see what other genes have been impacted and what those consequences are, if any.

  46. nymom says:
    @Anonymous

    Are you kidding me?

    How does being a ‘twitter leader’ require high IQ output. It appears to be the electronic version of what women do really well: talking about other people or gossiping as it used to be called…

    At best, it might be a form of manipulativeness IQ as you mentioned which is a form of intelligence probably women evolved to perfection.

    Twitter leaders are generally women like the Kardashians, clearly not high IQ…

  47. JMcG says:
    @Kronos

    Isn’t V-S the area where Aborigines are supposed to be very strong? That’s really an interesting question.

  48. nymom says:
    @donvonburg

    Yet the gypsies, when they came from India into Europe, were initially accepted because they knew the craft of making their own weapons from iron ore.

    They might have evolved over the years into having these other people-reading skills; but, I don’t think putting them into a machine shop would be overtaxing their IQ abilities as much as you think…

    • Replies: @Romanian
  49. @Kronos

    If you had to choose strictly between a verbal or visual-spatial bump which one would you choose?

    I think high verbal gets a better return in the marketplace.

    It’s an interesting question, though, to ponder how changes in your cognitive abilities might affect your subjective experience of life — basically your “consciousness.”

    But I suppose there is ultimately no good way to study or analyze inherently subjective experiences.

    • Replies: @Global citizen
  50. @donvonburg

    That’s an amazing, thought-provoking post.

  51. @donvonburg

    Irish Travellers AFAIK maintain their own vehicles and the diggers and rollers used to tarmac drives and lay block paving, so they’re not daft.

    They’re actually pretty well adapted to modern liberal UK society, with its tax-funded grievance groups/lawyers and hate laws. For example, if you object to a proposed traveller site on grounds of increased crime, that’s racist and the local authority will literally ignore your objection.

    In Ireland they made trespass a criminal rather than civil offence, at which point most moved over here, while maintaining property back in Ireland.

    Quite a few minority groups are successful in a society where the system is biased against its own people.

  52. Thirdtwin says:

    Call me when they isolate the Black Hair Gene. *That*will be historic.

  53. @MikeatMikedotMike

    Can someone invent a “supercell” that makes sickle cell MORE deadly?

    • Replies: @Hail
  54. Anonymous[354] • Disclaimer says:
    @Steve in Greensboro

    The problem with DDT is its effect on birds not bugs.

    • Replies: @Steve in Greensboro
  55. Anon[281] • Disclaimer says:
    @Global citizen

    For someone who complained about the John Money / David Reimer fiasco just last week, Steve Sailer is unreasonable excited. The article states that it’s only one individual, whose cure began miraculously on July 2nd. But (((they))) write amazing press releases, propping up their (((institutions of higher learning))) otherwise committed to Jewish privilege.

    This morning I could read George Church bleatings, but nothing on how Mojica’s and Barrangou’s discoveries were appropriated by Doudna and Charpentier. Nothin on how MIT/Harvard is patenting stuff they haven’t dreamt of. Nothing on how CRISPR is an acquired genetic improvement passed on, at least in bacteria, to descendents, in pure Lamarckian fashion. CRISPR is a Lysenkoist wet dream coming true. But, yeah, let’s hear George Church, the Soap-allergic Stallman of genetics, the Delirious Caleb Harper who will develop the Escherichia Computer at a date TBD.

    “Remember when gene therapy was a miracle, priced at 1.2 million, only to be unceremoniously cancelled by immune rejection?” “Well, I don’t, because all I care about is blacks something-something”.

  56. Anon[410] • Disclaimer says:
    @Glaivester

    Good thing red blood cells still have tens of surface antigens, and their predecessors are even more studded with CD molecules. Moreover, NK cells kill any cells expressing unusual / defective molecules, as well as cells that don’t express normal, healthy surface molecules.

    It’s so widely believed that the immune system cleans up slightly changed cells, that the American government spent tens of billions on Biden’s “moonshot”. That is literally a bet that drugs can prop up the immune system to kill slightly changed cells (that is, cancer cells).

    Now, cancers are bulky, and Biden’s little cells are a crap idea. But the few genetically modified cells that have nested in this woman’s bone marrow are likely a handful. If anything survived from her old immune system, a “sad” and “unexpected” immune rejection will happen around Christmas, due to rejection of the said stem cells. If nothing survived of the old immune system, well, there’s a 25% rate of failure in marrow transplants.

  57. @Kronos

    Being an Ok Boomer I had to sleep on it and get a cup of coffee.

    I have reasonable VS and verbal already, don’t need more of either. What I really need to do is to slow down and check it out before commenting when I see something interesting.

    VS = Origami/make stuff of all sorts
    Verbal = Argue/critique
    VS + Verbal = Visualize and make modified cells, then publish article and market them (simply put as verbal is also needed to write grant proposal in first place)

    We all know what the best bump bump is!

    • Replies: @J.Ross
  58. @Hypnotoad666

    But I suppose there is ultimately no good way to study or analyze inherently subjective experiences.

    That’s Litrachure, dear.

  59. Jack D says:
    @Anonymous

    The previous thread on changing demographics didn’t mention that swapping comparable IQ asians for whites will produce profound change in the society. IQ is complex.

    Yes and no. Certainly modern Asian societies are somewhat different than American societies in their social structures but the tangible results are not that different – people in S. Korea or Japan live at a similar standard of living, have similar (democratic) political structures. They drive similar cars, play similar video games, have similar systems of medicine, higher education, sports, wear similar clothes, etc. I guess it depends what you mean by “profound”.

    Changing demographics in hgh iq niches is not IQ driven I conclude. We see white male gentiles declining in top school enrollment and top job niches in modern America and yet there is no evidence within the huge data set known as the internet that white male gentiles are lagging other groups in intelligence. Along with the erosion of white male status in various niches out in the real world we should see a correlation on the internet. E.g white male gentiles should not be leaders on twitter or the blogosphere or anywhere else on the internet that requires high IQ output.

    Your conclusion is wrong. Even holding all other things equal, white male gentiles are a declining % of the population so they would decline in school enrollment and top job niches even if their relative intelligence remained the same. But it’s not the same. Certain recent immigrant groups have higher mean IQ than whites (especially since we aren’t getting a random cross section but a pre-selected group, e.g. of S. Asian) and so are going to form an increased % of the high IQ elite over time. The AVERAGE Indian is nothing to write home about but there are a BILLION of them so if you pick out the smartest million or ten million of them they are going to be pretty sharp.

    I don’t know that anyone has done any formal study of white leadership on the internet vs. the real world. I think this may be a “blind man and the elephant” issue from your POV – in the PARTS of the internet that you touch, white men still have leading roles but your aren’t seeing the whole internet.

    • Replies: @Johann Ricke
    , @Odin
  60. Jack D says:

    On the other hand, what if you had one negative mutation? Could that drive down your IQ notably and could it be fixed by this type of technology?

    There are a few single gene mutation genetic diseases aside from sickle cell (and these will be among the first cured by gene editing) but most of them kill you when you are pretty young. For example Tay Sachs disease affects your nervous system and causes cognitive decline. But it also affects the rest of your nervous system so you also lose the ability to control you motor system, vision, hearing, etc. and then you die. So if you have this disease then mental retardation, as bad as that is, is the least of your problems. Other mututations (e.g. cystic fibrosis) don’t seem to affect intelligence because they are connected to something that has nothing to do with the nervous system (e.g. the respiratory system).

    The other thing to know about single mutation diseases is that most of them are recessive and can be prevented thru the use of genetic screening. If you have one copy of the gene, it is harmless (indeed beneficial in some context, which is why it is in the population to begin with), but TWO copies gives you the disease. There is no need to “fix” these diseases if no children are born with them in the 1st place.

  61. Element59 says:
    @donvonburg

    “Likewise Australian aborigines might have IQs in the 65 range but even as kids they can set out on foot across the outback and survive where only the most highly trained and well conditioned military commando types amongst whites would even have a chance-and probably beat the commando to where they are headed.”

    Ironically I’ve seen this exact same argument employed by rabid IQ deniers as proof of the concept of IQ being falsified. They believe that this reasoning demonstrates the superior “intelligence” of Aboriginals. The retort to this line of argumentation is that even our primate cousins, with IQs far below that of humans and without any formal “training” or exposure to human ways, function quite optimally and thrive in difficult natural ecologies that most intellectually superior humans could not. Gray whales can navigate from Alaska to Baja, feed, give birth, nurse, and return to Alaska without any formal navigation or reproduction training.

    Is this proof that humans are not more intelligent than primates or whales? No, it’s evidence of evolved instincts and senses that are the primary drivers of survival in animals. Humans evolved general intelligence (g) and abstract reasoning which became more and more useful as early non-tribal societies developed in agrarian economies. IQ reflects the sophisticated cognitive skills and abstract reasoning that are very useful to function and thrive in industrialized societies, so it’s indeed measuring something tangible. If one does not score well on an IQ test, they are probably more likely to be dysfunctional to some degree in an advanced society.

  62. @donvonburg

    Lots of truth to this.

    Now, Chinese society has prized the ability to take tests, such as Imperial Chinese civil service exams for thousands of years. I wonder if those who were really good at taking tests therefore had an advantage through what is called sexual selection: good test takers had more money, which is a secondary survival trait, which was attractive to Chinese females, and thus they could have multiple wives and tons of children.

    Sexual selection explains the evolution of the male peacock’s tail. A large beautiful tail has absolutely no evolutionary benefit, and is actually a drag on the peacocks’ resources. But the tail attracts peahens.

    • Replies: @J.Ross
    , @anon
  63. J.Ross says:
    @Paleo Liberal

    That’s been claimed roughly (more like “winners are more likely to come from winners”), but also Chinese believe in swotting for its own sake, the Classics would take a lot of time to read and analyze, and lower class people simply didn’t have the time to study even if they had access to the books.
    But now our elite are people like the Soviet spy’s grandchild at Chapo Trap House.
    ————–

    https://en.interfax.com.ua/news/press-conference/625876.html

    Biden, partners receive $16.5M in payments stolen from Ukraine – MP Derkach

    KYIV. Nov 20 (Interfax-Ukraine) – Some $16.5 million received by Hunter Biden, the son of former U.S. Vice President Joe Biden, as payment from Burisma was stolen from Ukrainian citizens, member of parliament Andriy Derkach has said.

    [MORE]

    Derkach said at a press conference at the Kyiv-based Interfax-Ukraine news agency that on November 14 the Prosecutor General’s Office (PGO) announced a new suspicion to the owner of Burisma, former Ecology Minister Mykola Zlochevsky.

    “The PGO document once again confirms the data I had previously published on Burisma and international corruption. According to Zlochevsky’s suspicion notice, Biden and partners received their $16.5 million for their services to Burisma. Biden received funds not due to the successful activity of Burisma or for brilliant business decisions or recommendations. This is the money of Ukrainian citizens. The funds were obtained by criminal means. That’s what they say in the PGO,” Derkach said.

    Derkach said the new suspicion notice to Zlochevsky was received by him from investigative journalists.

    “According to the investigation, Zlochevsky was directly involved in the withdrawal of funds by the Yanukovych “family” (the Yanukovych criminal organization, according to the notice). They laundered the funds of Yanukovych through three companies in Latvia,” Derkach said.

    As reported, on October 9 Derkach made public official correspondence between the National Anti-corruption Bureau of Ukraine (NABU) and the U.S. Embassy, according to which First Deputy NABU Director Gizo Uglava through his assistant Polina Chizh provided the U.S. Embassy with information that affected the course of events in Ukraine and the United States.

    According to him, Chizh received an order from U.S. Embassy employee Hanna Yemelyanova to provide information on the case of Ex-Ecology Minister and Burisma Group owner Mykola Zlochevsky.

    Zlochevsky revealed the amount of money that was transferred to the representatives of Burisma Group, including Hunter Biden. According to the documents, about $16.5 million was transferred in favor of Hunter Biden, Aleksander Kwasniewski [globalist author and, for ten years in the Shock Therapy period, the President of Ukraine’s neighbor Poland], Alan Apter [Columbia-educated investment banker formerly at Morgan Stanley, now Burisma’s Chairman of the Board], and Devon Archer [*].

    According to Derkach, Ex-Prosecutor General Viktor Shokin repeatedly contacted NABU Director Artem Sytnyk in the framework of criminal proceedings involving Burisma, but constantly received formal replies. The activities of Shokin, according to Derkach, irritated Joe Biden during his fifth visit to Kyiv in two years on December 7-8, 2015. The visit was devoted to the issue of removing Shokin as Prosecutor General and the affairs of Zlochevsky and Burisma.

    “The instrument issued for pressure was the $1 billion credit guarantee that the United States should have provided to Ukraine: Biden himself acknowledged the pressure in his speech to the U.S. Foreign Relations Council in January 2018,” Derkach said.

    On November 11, Derkach said on his video blog that Head of the Specialized Anti-corruption Prosecutor’s Office (SAPO) Nazar Kholodnytsky launched an investigation into his allegations that the NABU had provided information to the U.S. Embassy in Ukraine. He also noted that from May 2014 until October 2015, Burisma transferred $4.817 million to Rosemont, and the latter transferred $871,000 to Hunter Biden.

    *
    https://www.justice.gov/usao-sdny/pr/three-convicted-manhattan-federal-court-fraudulent-issuance-and-sale-more-60-million

  64. J.Ross says:
    @Global citizen

    “OK Boomer” was specifically coined and propagated on 4chan before the 2016 election to mock the blithe ignorance of immigration problems (and Obama’s crime spike).
    >If Ashok hires ten of his relatives instead of you, that must be because you aren’t as good as ten of his relatives.
    >Okay, boomer.
    If you’re here, you’re probably not ignorant of immigration problems.
    Reducing the line to contextless, meaningless generational hate is infowar damage control by what Mencius Moldbug calls “The Cathedral.” To this end there is discussion of an “OK Boomer” sitcom, which would probably be a reboot of That Seventies Show, more in the style of Big Bang Theory, with a Dharma and Greg style pseudo-contest over the appropriateness of polyester clothing.
    “OK Boomer” is mocking all the people who don’t see what’s wrong with open borders, bluntening it is serving the hivemind.

    • Replies: @Global Citizen
  65. kihowi says:
    @donvonburg

    That’s an argument my relative loved to abuse. Maybe Africans are geniuses at building straw huts and showering in cow piss! You don’t know!

    Yeah, maybe. But the idea of IQ exists because we have a vague idea that some people can think quicker and have more thoughts at the same time than others, and therefore do better at complicated things. Unfortunately for blacks, the “do better” is defined as do better over here in the way that we understand it. I’m well willing to accept that Jamal the habitual criminal would be the most badass chieftain in Africa, but it’s not very important.

  66. @Jack D

    The AVERAGE Indian is nothing to write home about but there are a BILLION of them so if you pick out the smartest million or ten million of them they are going to be pretty sharp.

    I have to wonder how much of that is due to malnutrition. It’s said that 1 out of 3 Indian children is malnourished. That’s got to affect cognitive development.

    https://www.npr.org/sections/thesalt/2015/07/14/422592127/egg-wars-india-s-vegetarian-elite-are-accused-of-keeping-kids-hungry

  67. @Anonymous

    No. DDT does not need to be used that heavily. All that needs to be done is to spray the walls inside of houses where people sleep. Malaria mosquitoes fly in and turn around and fly out. (DDT is not really a very effective insecticide. It is more an insect repellent.) A generation of the the malaria microbe not being able to find a home in humans and the microbe is extinct as it is in the U.S.

    No need to “sacrifice” tropical birds to save human lives (although if it were my kids, I’d be OK with that trade). Just use the chemical correctly.

    But of course, Western environmentalists are perfectly OK with condemning black kids in SubSaharan Africa to a crippled life to reduce a vanishingly small risk to tropical birds. And of course that helps trigger SubSaharan immigration to the West.

  68. anon[252] • Disclaimer says:
    @Paleo Liberal

    Chinese Civil Servants were always eunuchs.
    It wasn’t a bad system, since it prevented bean counters and paper shufflers from passing on their genes.

    • Replies: @dfordoom
    , @Alden
    , @Daniel Chieh
  69. this would be an important breakthrough, and it’s work worth doing.

    with the caveat that others have already covered. why help africans?

    it’s an indirect effect in the pursuit of medical and scientific excellence, but my mind always complains – hey man, that’s enough already with the doing stuff to make sure there are another billion africans around.

  70. Romanian says: • Website
    @nymom

    Well, we don’t know how they came into Europe, but we know they ended up as slaves to boyars and monasteries in occupational castes. None were for weapons, and slaves generally don’t have weapons. As late as a few decades ago, you would have your pots fixed and your knives sharpened by itinerant groups, as well as music and dancing bears provided for weddings and the like.

    • Replies: @Alden
  71. @gcochran

    “It started in West Africa, about 7k years ago.”

    so for 100,000 years africans went without it? what is the estimated fitness improvement for this mutation then? how many africans were around 50,000 years ago, versus say 5000 years ago after this mutation arose and spread? did survival rates go up 5%, 10%, more?

    obviously they can survive for millennia without it.

    • Replies: @gcochran
  72. @Anonymous

    “Unintended Consequences??? What about Sardinia, where it shows that after they killed all the mosquitoes with DEET in the 1940s, the lack of a malaria threat led to a scourge of autoimmune issues”

    one of the reasons i might not exterminate all viruses and most bacteria if i could just push a button and ‘clean’ the planet. not clear if that might screw things up really badly, even if you were selective, and exterminated the things which we’re pretty sure have zero useful function.

    i do think we could eliminate herpes from the entire planet with no negative side effects though. that virus just does nothing useful. and there are probably many like that.

    i do think long term, ‘cleaning’ the planet should be a goal. no extraneous microscopic life forms that have zero beneficial use. their 500 million year existence on the planet comes to an end after 2100. dead and gone forever with zero chance they could ever exist again or recur.

    then again that’s how super AI or vastly superior aliens might treat humans. as bacteria. we don’t even wonder about what tuberculosis thinks or even try to communicate with it. we simply eliminate it.

    • Replies: @Jack D
  73. Global Citizen [AKA "Global Citizens"] says:
    @J.Ross

    Ok, Whatever. All those nasty people can just Talk To The Hand!

    It’s OK to be a Boomer. Especially if your White.

    Is that a meme yet?

    BTW Joe Sobran was always interesting.

  74. dfordoom says: • Website
    @anon

    Chinese Civil Servants were always eunuchs.

    Are you really sure about that?

    • Replies: @gcochran
  75. gcochran says:
    @prime noticer

    Falciparum malaria, the worst kind, is also new.

  76. Anon87 says:

    “Innovation” is thrown around quite a bit these days, and for the most part is abused. There really isn’t much true innovation being done at Apple, Google, Facebook, Uber, etc.

    CRISPR on the other hand seems like the biggest scientific advancement since we landed on the moon. CRISPR is innovative, and I am surprised it isn’t more well known.

  77. @Not Raul

    This may have brought the disease to India.

    And New Zealand?

    It could just be that malaria is a tropical thing, and a resistant mutation pops up independently now and then.

    The HbS mutation has occurred on at least three occasions in Africa, named after the areas where these were first described3, Benin, Senegal and Bantu (Central African Republic) and referred to as the beta globin haplotypes. A separate and fourth occurrence of the mutation was seen around the Arabian Gulf and India and designated the Arab-Indian or Asian haplotype4.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822363/

  78. Jack D says:
    @prime noticer

    That’s what we’ve done with the smallpox virus. There may be some samples locked up in bioweapons lab freezers, but it’s completely extinct in the wild. Humans have caused the extinction of numerous species, often highly beneficial ones so getting rid of a few disease causing organisms is not so bad.

    • Replies: @Romanian
  79. Alden says:
    @danand

    Cancer in dogs is exploding because of made in China dog food according to several veterinarians I know. They recommend feeding dogs cheap meat on sale including raw chicken and turkey necks. The raw bones are soft enough they don’t hurt the dogs. Some turkey slaughter houses don’t boil the necks into soup any more They freeze and package them for sale to dog owners.

  80. Alden says:
    @Romanian

    I’ve always wondered about gypsies as slaves. Seems to me they would be absolutely worthless.

    • Replies: @Romanian
  81. Alden says:
    @anon

    Only those who had to do with, and lived in, the households and harems of lords and Emperors were eunuchs.

    Most were married lived in their own households and had children

  82. Odin says:
    @Jack D

    The AVERAGE Indian is nothing to write home about but there are a BILLION of them so if you pick out the smartest million or ten million of them they are going to be pretty sharp

    Do we know which of the populations back home their mean will regress toward?

    • Replies: @Jack D
  83. Hail says: • Website
    @Daniel Williams

    Genius T. Pac Shakur on Sickle Cell Anemia:

    We millionaires!
    Killin’ ain’t fair, but somebody gotta do it

    Oh yeah, Mobb Deep [rival rap group], you wanna f*** with us?
    You little young-a** motherf*****s
    Don’t one of you ni**as got sickle-cell or somethin’?

    You’re f***in’ with me, ni**a
    You f*** around and have a seizure or a heart attack

    You better back the f*** up
    Before you get smacked the f*** up
    This is how we do it on our side!

    Any of you n****s from New York that wanna bring it, bring it!
    But we ain’t singin’, we bringin’ drama
    F*** you and yo’ motherf****n’ mama!

    Very charming.

    • Replies: @Daniel Williams
  84. Hail says: • Website
    @Herbert West

    Rumor has it the Chinese have race-specific biological weapons.

  85. Romanian says: • Website
    @Alden

    We wouldn’t know. Slavery was not a democratic institution around here, unlike with the Romans and others, so slaveholding was for elites, who are a very small class in a low productivity feudal society.

    They just have to be worth more than the lowest possible cost of sustaining their individual lives – the marginal cost of the slave worker.

    A recent movie on hired hands tracking down an escaped slave.

    Epic dialogue I remember from it.
    “What did you do to the boyar’s wife?”
    “I came inside her”

  86. Romanian says: • Website
    @Jack D

    And rinderpest! Would have been polio, too, but it remained in Pakistan and a few other areas that were uncooperative and has made a small comeback.

  87. @Hail

    I agree with you about Tupac. We lost him too soon. But at least we can cherish his poetry and one day pass it along to diss future generations of bitch-ass niggas with sickle cell.

    Unless these scientists cure it, that is.

  88. Jack D says:
    @Odin

    Indian society is not uniform – they have been stratified into castes for 2,000 years and most of the high IQ individuals are also high caste individuals. So there is no one group mean, there are caste means and caste mean of say Brahmins is probably quite high.

    https://akarlin.com/2012/08/the-puzzle-of-indian-iq-a-country-of-gypsies-and-jews/

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