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Screenshot 2016-09-05 12.27.38
For whatever reason I missed this paper which came out in July in AJHG, Human Y Chromosome Haplogroup N: A Non-trivial Time-Resolved Phylogeography that Cuts across Language Families. Basically it blows up sample size and utilizes NGS techniques (whole-genome) to resolve some questions around haplogroup N, and in particular the M46/TAT subclade which exhibits a peculiar geographic distribution, from the shores of the Baltic to easternmost Siberia.

Screenshot 2016-09-05 12.33.34 I actually blogged about this as far back as 2003, so it’s a long term mystery. There’s no autosomal rhyme or reason to the frequency of this lineage. Yes, there is a vague Uralic affinity, but this Y chromosomal variant is higher in the Lithuanians than the Finns, and found in peoples as distant as the Koryaks. One of the major early questions was whether it was a marker that indicated east-west movement, or west-east movement. In other words, was it associated Siberian ancestry in Finns and affiliated people, or did it indicate European ancestry in Siberian people?

Rurik, carrier of N1c

Rurik, carrier of N1c

If the results in this paper are correct the likely answer is: none of the above. The core TAT lineage looks like it underwent an explosion ~5,000 years ago. This is around the same time as Northern Europeans and Siberians as we understand them were coming into being. So the TAT lineage didn’t come with a specific people, it was part of the process which made the people. I’ll quote from the discussion:

Overall, a considerable proportion of men inhabiting much of the Arctic and temperate zones of western and eastern Eurasia share N3a3’6 lineages that date back to the mid-Holocene (4.5–5.0 kya). This common patrilineal ancestry unites widely different linguistic phyla, including Indo-European, particularly Balto-Slavic, branches of the Altaic, such as the Mongolic, Turkic, Tungusic, and Chu- kotko-Kamchatkan branches, as well as the Balto-Finnic branch of the Finno-Ugric.

The autosomal genome-wide data is clear, pretty much all the Finnic peoples in Europe seem to have a small (to various degrees, with Finns proper the least), but clear, signal of admixture that is Siberian. It is tempting to associate this with the men who carried TAT into these populations, but observe that the Lithuanians seem to be lacking in this signature. Y chromosomes and autosomes are not always in alignment, but recall that many Siberians have some West Eurasian ancestry, some of it likely quite ancient, and carry R1a1a Y chromosomes. The past was more complex than we had assumed, and the relationship between movements of men and languages is likely not so straightforward in the inferences we can make. It may be that the Siberian admixture into Finnic peoples, and their linguistic identity, post-dates the arrival of TAT into the far north of Europe.

One of the aspects of the explosion of many Y chromosomal lineages 4-5,000 years ago is how much they don’t associate well with ethno-linguistic boundaries. The “Indo-Aryan” R1a1a in South Asia is very common in some low caste South Indian tribal populations. The R1b brought by the Corded-Ware culture, which presumably transmitted Indo-European languages, is at very high frequency among the non-Indo-European Basques, as well as groups such as Sardinians, who were Indo-Europeanized only in Classical Antiquity. The Y lineages seem to expanded far beyond the totality of the cultural unit.

Genetics is giving us lots of data. But there are no theoretical bones to scaffold this flesh.

 
• Category: Science • Tags: Finns, Genetics 
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The Fennoscandia Project has now gone through chromosomes 1 to 6 with Chromopainter/fineSTRUCTURE. The conclusion:

If we looker at the bigger picture we see that most of continental Europe is tied to each other more trough mutations than others making them harder to seperate even at this level (6 chromosomes). We see that Lithuanians seem to have stronger affiliation to the large continental European cluster including Scandinavians but this affiliation is weaker for Vologda Russians. This connection is even weaker for Finns and almost non-existing for Saamis. This is in accordance with the MDS plot.

Here is the relevant plot (I have added some labels):


The Vologda Russians from the HGDP data set clearly have a substantial Finnic ancestral component. That’s because Russia, as the domains populated by Russians, has been expanding north and east for nearly 1,000 years. Much of this occurred via assimilation and acculturation of non-Russian Uralic and Altaic populations.

As for the relatively close affinities of the various Finnic peoples, why? There are parts of Finland where it seems that there has been very strong founder effect due to recent expansion of settlement north. But I do not understand how this would relate to the connection with the Sami and other Finnic and Finnic-origin peoples to the east. My own earlier supposition has been that northeast Europe served as a repository of peoples who adopted agriculture late, and were resistant to the expansion of Indo-Europeans. This certainly comports with the fact that there is a rather sharp difference between Finnic and Scandinavian peoples in Norden. Yet the Finnic people are not an archive of deep ancient genetic diversity, as is in the case of African populations such as the Pygmy and Bushmen. But perhaps the African model is not appropriate, as Eurasian populations start from a far lower baseline of genetic diversity? In that case one can imagine that the retreating hunter-gatherers on the boreal fringe may always have been subject to strong genetic drift because of the marginality of their local ecology.

(tip Maju)

(Republished from Discover/GNXP by permission of author or representative)
 
• Category: Science • Tags: Finns, Human Genetics 
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800px-Cross-cutting_relatio

At Genomes Unzipped Luke Jostins elaborates on how the genetic facts he now has about his paternal lineage change how he views his own personal history:

… my father’s father is Latvian, and the N1 haplogroup is not rare in the Baltic regions. In fact, the subgroup, N1c1, is more common in parts of Eastern Europe than it is in Asia.

Initially, this seemed to play nicely into a part of our ancient family history. There is a folk history, relayed to me be my Dad and my uncle Johnny, that Jostins blood may contain traces of Mongolian. The justification for this is that in around 1260, just before the civil war caused the Mongol Empire to die back in Europe, the Empire extended all the way to the Baltic States. It was at this point, my fellow N1c1-bearers hypothesise, that Mongolian DNA entered the Jostins line.

Unfortunately on closer inspection this tale is not really supported by the DNA evidence. The famous Mongol Expansion haplogroup is actually C3, which is the modal haplogroup of Mongolians. In contrast, N1c1 has existed in Europe for thousands of years, and is far to old and too wide-spread to represent a recent expansion.

dnanlargergTo the left is a frequency map of the concentration of N1c1. Based on the current distribution, and the diversity being modal in the East Baltic, one has to be skeptical of a simple east-west model. Interestingly the frequency difference of this haplogroup between Finland and Sweden is very high. Also, branch of N1c1 seems to be found among the Rurikids of Russia. This was the ruling dynasty of the Rus, a people who originally seem to have been ethnic Scandinavians from Sweden. Eventually they ruled over a polyglot state of Finns, Slavs and Scandinavians, and submerged their own identity with that of the Slavic peasants. In this they followed the example of the Bulgars, who were ethnically distinctive from their Slavic subjects, but were totally absorbed excepting that their ethnonym persisted. There is some evidence that the Serbs are a similar case, an Iranian group which was eventually absorbed into the South Slav substrate.

Going back to northern Europe, let’s try to get some more perspective. Luke Jostins’ personal history is after all a slice of population history, and what we know about the background of the population impacts how Luke views his own personal history. To do that I thought I’d quickly poke around a few older papers on Baltic genetics which I had stashed away. It didn’t turn out to be so quick. But here are some figures. First, from Genome-Wide Analysis of Single Nucleotide Polymorphisms Uncovers Population Structure in Northern Europe:

finplos

From Genetic Structure of Europeans: A View from the North–East:

fi

Finally, from Migration Waves to the Baltic Sea Region (N3 = N1c1):

finfinal

Also see my recent posts on Northern European genetics, as well as the argument about agriculturalists vs. farmers. Ten years ago we have a few simple models, but now it gets more confusing and complicated. Confounders:

- Different reproductive skew parameters for males and females. In short, high fertility of “super-males” as well as dominance of patrilocality can produce different patterns in Y and mtDNA

- Selection on mtDNA. The “neutral” markers which we think of as neutral may not be neutral

- Poor correspondence between inferences of the past based on contemporary patterns of variation and what ancient DNA has discovered. Our assumptions are faulty, or we’re just too stupid to extract the real patterns

- Persistent problems with dating and typing some uniparental lineages. Consider the debate over the pan-Eurasian haplogroup R1a1a* (Dan MacArthur and I both carry this Y lineage, but what’s in a few letters?)

- Reality is complicated. This may be the most intractable issue over the long term

I have used the analogy of a palimpsest to describe the flow of genetic variation over time and space. I think that perhaps that that is misleading in some fundamental ways. Demographic patterns are characterized by different dynamics, persistent and long standing “flows,” as well as punctuated “explosions.” Rather than a palimpsest, a better analogy might be the layering of geological strata. Although there are long periods of gentle wearing and layering, volcanism and earthquakes periodically erupt to disrupt the smooth accumulations. Sequences of catastrophic events can produce inversions.

Consider three dynamics:

- Isolation-by-distance. This is the conventional band/village-to-band/village process of gene flow. This may be analogized to sedimentary accumulation (mutations) and erosion (drift)

- Demic diffusion. The rapid demographic expansion into virgin territory by a culture which introduces a more efficient mode of production. One of the most recent occurrences of this was the rapid multiplication of New England Puritans from ~30,000 circa 1640 to over 700,000 150 years later. Not only did these New Englanders “fill up” their home territory, in the early years of the republic they burst out of the northeast and populated many regions of the Great Lakes. Demic diffusion is like an earthquake, a rapid and ordered shift of the local geology

- The leap frog. The settlement of Europeans in the southern cone of Latin America, Australia, or Mongols in eastern Iran, are instances of leap frogs. We have clear textual of these leap frogs, but without that we wouldn’t know what to make of them. Leap frogs are like volcanic eruptions, reordering the layers beneath and also deposition from above

At least with Luke’s hypothesis about descent from Rurik he can test his own N1c1 profile against other Rurikids. Presumably the modal haplotype and its near relations are those of the original Rurik.

(Republished from Discover/GNXP by permission of author or representative)
 
• Category: Science • Tags: Finns, Genetics, Genome, Genomes Unzipped, Genomics 
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Razib Khan
About Razib Khan

"I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. If you want to know more, see the links at http://www.razib.com"