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I am travelling much of this week with the family. So expect me to be “off the grid” a bit.

But I will check this thread every day or so.

 
• Category: Ideology

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The above model of the settlement of the Americas is from a new paper which utilized ancient mtDNA, Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas (open access):

The exact timing, route, and process of the initial peopling of the Americas remains uncertain despite much research. Archaeological evidence indicates the presence of humans as far as southern Chile by 14.6 thousand years ago (ka), shortly after the Pleistocene ice sheets blocking access from eastern Beringia began to retreat. Genetic estimates of the timing and route of entry have been constrained by the lack of suitable calibration points and low genetic diversity of Native Americans. We sequenced 92 whole mitochondrial genomes from pre-Columbian South American skeletons dating from 8.6 to 0.5 ka, allowing a detailed, temporally calibrated reconstruction of the peopling of the Americas in a Bayesian coalescent analysis. The data suggest that a small population entered the Americas via a coastal route around 16.0 ka, following previous isolation in eastern Beringia for ~2.4 to 9 thousand years after separation from eastern Siberian populations. Following a rapid movement throughout the Americas, limited gene flow in South America resulted in a marked phylogeographic structure of populations, which persisted through time. All of the ancient mitochondrial lineages detected in this study were absent from modern data sets, suggesting a high extinction rate. To investigate this further, we applied a novel principal components multiple logistic regression test to Bayesian serial coalescent simulations. The analysis supported a scenario in which European colonization caused a substantial loss of pre-Columbian lineages.

The key here is that looked at whole mitochondrial genomes, which gives them more information to work with. Earlier work often focused on a particular variable region of the mitochondrial genome. And, mtDNA is copious, so they got good quality data from all of their samples (really 5x is decent for population genomic work, and that was the worst). Combined with the fact that they had ancient genomes, which allow them to investigate the phylogeny in a more precise manner temporally, and have you the potential to make some really strong inferences.

F3.large Figure 3 in the paper makes everything really clear. The last common ancestors between Native American mtDNA lineages and those of Siberians is >20,000 years before the present. That is, before the Last Glacial Maximum. The next major feature you see is an explosion of lineages aroun ~15-16 thousand years ago. This is the hallmark of a rapid population expansion. But after the initial period of diversification you see the persistence of a lot of deeply divergent lineages. Additionally, further population genomic modeling indicate that there was a major extinction event ~500 years ago, no doubt due to the Columbian Exchange and the arrival of Old World populations and their diseases.

This paper is fundamentally about Native American historical genetics. It is another nail in the coffin of the “Clovis first” model of Amerindian origins. Basically, that the Clovis group of megafaunal hunters were the First Americans. No, it does seem likely now that modern humans were present in portions of the New World thousands of years before Clovis. The Monte Verde site’s occupation on the Chilean coast less than two thousand years after the opening of a coastal route from Beringia indicates that perhaps there was a strong focus on marine environments for a significant period of time. Once the New World was settled there seems to have been a lot of persistent population structure, until the arrival of Europeans, at least in comparison to what ancient DNA has told us about Europe. Additionally, the long isolation of the Beringians is also significant in my opinion.

In a world of billions of humans it may be that we lack proper intuition for how little gene flow may have occurred between populations in a sparsely populated globe. The Beringians were separated from Siberians for on the order of ~5,000 years. It only takes ~1 migrant between two populations per generation to prevent them from drifting apart in allele frequencies, so the gene flow was very low (this is mtDNA, so not strictly applicable, but the same logic holds). But it is possible that in much of northern Eurasia during the Last Glacial Maximum humans retreated to zones of survival, and vast swaths of territory became empty. This would result in islands of human habitation diverging and become very different over several thousands of years. In sharp contrast, the world over the past 4,000 years or so has been characterized by the ability of humans to travel long distances over inclement territory, and settle amongst strangers, usually through conquest. Partially this is due to the domestication of the horse, but partially it is probably due to the emergence of high density complex societies which can incubate specialist castes whose role arose initially as defense, but who often engage in offense whenever the opportunity arises.

 
• Category: Science • Tags: Genetics, New World

About one week ago I wrote about bilingual education, and I admitted my mild skepticism about the research about the benefits of bilingualism. A friend emailed me and wondered why I was only “mildly skeptical.” Partly I didn’t want the comments to get sidetracked, but recently friends on Facebook have started to get exercised that Ron Unz is running for the Senate, and how bad he is for not giving the children the opportunity to be bilingual. And of course all the research that confirms how great bilingualism is referenced.

So here’s an article from last month that my friend sent me. I’ll quote the appropriate section, you’ve seen this movie before, The Bitter Fight Over the Benefits of Bilingualism: For decades, some psychologists have claimed that bilinguals have better mental control. Their work is now being called into question:

But a growing number of psychologists say that this mountain of evidence is actually a house of cards, built upon flimsy foundations. According to Kenneth Paap, a psychologist at San Francisco State University and the most prominent of the critics, bilingual advantages in executive function “either do not exist or are restricted to very specific and undetermined circumstances.”

Paap started looking into bilingualism in 2009, having spent 30 years studying the psychology of language. He began by trying to replicate some seminal experiments, including a classic 2004 paper by Bialystok involving the Simon task. In that task, volunteers press two keys in response to colored objects on a screen—for example, right key for red objects, left for green. People react faster if the position of the keys and objects match (red object on right half of the screen) than if they don’t (red object on left). But Bialystok found that twenty Tamil-English bilinguals from India were faster and more accurate at these mismatched trials than twenty English-speaking monolinguals from Canada. They were better at suppressing the location of the objects and focusing on their color—a sign of superior executive function.

“It was a really exciting finding and one that I thought would be easy to study with my students,” says Paap. “But we just couldn’t replicate any of the effects.” After years of struggling, he published his results in 2013: three studies, 280 local college students, four tests of mental control including the Simon task, and no sign of a bilingual advantage.“That broke the dam,” he says. “Others started submitting negative results and getting their articles published.”

Jon Andoni Duñabeitia, a cognitive neuroscientist at the Basque Center on Cognition, Brain, and Language, was one of them. In two large studies, involving 360 and 504 children respectively, he found no evidence that Basque kids, raised on Basque and Spanish at home and at school, had better mental control than monolingual Spanish children. “I am a multilingual researcher working in a multilingual society,” says Duñabeitia. “I’d be very happy to see an advantage for bilinguals! But science is what it is. We find no difference and we have replicated it several times, in older adults, kids, and young adults at university.”

For example, one group of researchers analyzed 104 abstracts on bilingualism that were presented at scientific conferences. They found that 68 percent of abstracts that found an executive-function advantage were eventually published in journals, compared to just 29 percent that found no advantage. This publication bias, a common problem in psychology and science as a whole, means that the evidence for the phenomenon seems stronger than it actually is.

But Paap doesn’t think much of the published evidence either. He found that a bilingual advantage only shows up in one in six tests of executive function, and mostly in small studies involving 30 or fewer volunteers. The largest studies, involving a hundred or more, all found negative results.

The proponents of bilingualism as a cognitive benefit have reacted angrily. Read the whole thing. But it’s probably not a real strong effect if there is any at all. Just another battle in the replication wars….

 
• Category: Science • Tags: Psychology

One of the major distinctions pundits made between Al Qaeda and ISIS until recently is that the latter was not as fixated on the “far enemy” (the West) as the former. That seems born out by the evidence of their behavior, focusing on conquests in the Levant and Iraq, as well as ideological arguments (e.g., What ISIS Really Wants). The New York Times now seems to be making the case that that was all wrong, How ISIS Built the Machinery of Terror Under Europe’s Gaze:

For much of 2012 and 2013, the jihadist group that eventually became the Islamic State, also known as ISIS or ISIL, was putting down roots in Syria. Even as the group began aggressively recruiting foreigners, especially Europeans, policy makers in the United States and Europe continued to see it as a lower-profile branch of Al Qaeda that was mostly interested in gaining and governing territory.

“All of the signals were there,” said Michael S. Smith II, a counterterrorism analyst whose firm, Kronos Advisory, began briefing the United States government in 2013 on ISIS’ aspirations to strike Europe. “For anyone paying attention, these signals became deafening by mid-2014.”

In June of 2015 The New York Times wrote about the decapitation:

… Mr. Cazeneuve emphasized that while Mr. Salhi was known to have links to Salafists, he was not believed to have links with terrorist groups.

There was no indication that Mr. Salhi was aligned with the Islamic State….

Basically the media became a telegraph service for craven politicians who didn’t want to face the crisis. I observed that The New York Times recently referred to Molenbeek as a “fifth column.” That sort of language is something that politicians and the media try to avoid, both for prudential and ideological reasons. When these “isolated” attacks occurred a few years ago the conservative press ridiculed the characterizations of the politicians and the media. It turns out that they were right, and The New York Times is admitting it. This should give us even more pause in accepting the “analysis” of the established outlets. When the evidence is confronting them this starkly they’ve had to fess up that they weren’t scratching below the surface, and perhaps even had become a cat’s-paw in the toolkit of the political class. Though I will credit The New York Times that there has been a change of direction internally when you allow Muslim communities in the West to be characterized as a possible “fifth column.” Unfortunately in Molenbeek’s case that seems operationally correct, and the evidence was too strong to obfuscate for reasons of political and ideological expedience.

 
• Category: Foreign Policy • Tags: ISIS

It has recently come to my attention that David Reich has two post-doctoral positions open which might interest readers of this weblog. Since I really enjoy writing about the research that his lab produces it is in my interest that he find the right people to work on the projects that he has. If you are one of those rare people in the world who has a background in history and statistical population genetics or data science this might be for you! Here are the listings, ignore the deadline date as they have been extended:

1) Post-doctoral fellow: Ancient DNA

Our ancient DNA laboratory has pioneered large-scale studies of human population history with large numbers of samples simultaneously and we are looking for a highly motivated post-doctoral researcher with appropriate experience and interests to work on analysis of these data.

The successful candidate will have previous experience in a world class ancient DNA laboratory, as well as analytical and computer skills that allow exploration of large and complex genetic data sets.

Description of additional projects in our lab, as well as papers we have recently published, is provided here.

The position will be supervised by Dr. David Reich.

Please write to reich at genetics [dot] med [dot] harvard [dot] edu by March 1, 2016 if you are interested.

2) Post-doctoral fellow: Learning about history using genetic data

We are searching for a highly motivated post-doctoral researcher to join our group.

The successful candidate will have exceedingly strong statistical / mathematical / computational skills, and an interest in history. While a background in population genetics, bioinformatics or experimental biology is advantageous, it is not necessary. Our lab has the resources to not only analyze large public data sets, but also has access to some of the world’s best new genetic data, whether generated by collaborators or in our own laboratory. Possible projects are:

• Studying human history using data from present-day populations

• Studying human history using ancient DNA

• Studying the process of speciation and the mechanisms of natural selection and mutation using genetic data

Description of projects in our lab, as well as papers we have recently published, is provided here.

The position will be jointly supervised by Drs. David Reich and Nick Patterson, and will involve work at both Harvard Medical School and the Broad Institute of Harvard and MIT.

Please write to reich at genetics [dot] med [dot] harvard [dot] edu by March 1, 2016 if you are interested.

 

 
• Category: Science • Tags: Job, Reich lab

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The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans:

Some present-day humans derive up to ∼5% …of their ancestry from archaic Denisovans, an even larger proportion than the ∼2% from Neanderthals…We developed methods that can disambiguate the locations of segments of Denisovan and Neanderthal ancestry in present-day humans and applied them to 257 high-coverage genomes from 120 diverse populations, among which were 20 individual Oceanians with high Denisovan ancestry…In Oceanians, the average size of Denisovan fragments is larger than Neanderthal fragments, implying a more recent average date of Denisovan admixture in the history of these populations (p = 0.00004). We document more Denisovan ancestry in South Asia than is expected based on existing models of history, reflecting a previously undocumented mixture related to archaic humans (p = 0.0013). Denisovan ancestry, just like Neanderthal ancestry, has been deleterious on a modern human genetic background, as reflected by its depletion near genes. Finally, the reduction of both archaic ancestries is especially pronounced on chromosome X and near genes more highly expressed in testes than other tissues (p = 1.2 × 10−7 to 3.2 × 10−7 for Denisovan and 2.2 × 10−3 to 2.9 × 10−3 for Neanderthal ancestry even after controlling for differences in level of selective constraint across gene classes). This suggests that reduced male fertility may be a general feature of mixtures of human populations diverged by >500,000 years.

Take a look at the supplements for the functional stuff. I am not going to address that. Much of those results have been circulation or in other papers over the years. Rather, I want to highlight the variation in patterns of Denisovan admixture in non-Oceanian groups. Here is an important section:

Taken together, the evidence of Denisovan admixture in modern humans could in theory be explained by a single Denisovan introgression into modern humans, followed by dilution to different extents in Oceanians, South Asians, and East Asians by people with less Denisovan ancestry. If dilution does not explain these patterns, however, a minimum of three distinct Denisovan introgressions into the ancestors of modern humans must have occurred.

You see it on the figure above. The South Asian groups consistently jump well above the trend line for inferred Denisovan as a function of shared ancestry with Australians non-West Eurasian ancestry. Also, if you look at the admixture patterns for Denisovan ancestry in South Asia you see they follow the ANI-ASI cline. That is, it seems to come into the South Asian populations through the “Ancestral South Indians.” Interestingly, the Onge sample of Andaman Islanders has less Denisovan than low caste South Asian groups, reminding us that though the Onge and their kin are the closest modern populations to the ASI, they are not descended from the ASI. The highest fraction of inferred Denisovan is in the Sherpa people of Nepal.

sherpa The figure to the right is from Admixture facilitates genetic adaptations to high altitude in Tibet, and the authors find that the Sherpa are at one extreme in an ancestry cline in comparison to other East Asians. The figure is hard to make out, so I will tell you that many of the Sherpa are fixed for the red component, while other Tibetans are in positions in the middle, and most East Asians have low fractions of the red, with the Dai having none. The Gujarati sample form the HapMap have low fractions of both East Asian components. This is almost certainly an artifact of the shared ancestry of all eastern Eurasians (and perhaps Oceanians), of which the ASI were one descendant group. The proportion of Denisovan in low caste South Asians indicates that the fraction in ASI was about at the same level as the Sherpa. I suspect that ASI and the Tibetan groups got their Denisovan via different paths, but it doesn’t seem like we know yet.

Overall I do marvel at what ancient DNA can tell us. Without it we wouldn’t be talking about any of these admixture events; they’d be signals too weak to have left an obvious mark in the genome.

 
• Category: Science • Tags: Denisovan, Neanderthal

Sardinian actress

Sardinian actress

Several years ago a paper was published, The History of African Gene Flow into Southern Europeans, Levantines, and Jews:

Previous genetic studies have suggested a history of sub-Saharan African gene flow into some West Eurasian populations after the initial dispersal out of Africa that occurred at least 45,000 years ago. However, there has been no accurate characterization of the proportion of mixture, or of its date. We analyze genome-wide polymorphism data from about 40 West Eurasian groups to show that almost all Southern Europeans have inherited 1%–3% African ancestry with an average mixture date of around 55 generations ago, consistent with North African gene flow at the end of the Roman Empire and subsequent Arab migrations. Levantine groups harbor 4%–15% African ancestry with an average mixture date of about 32 generations ago, consistent with close political, economic, and cultural links with Egypt in the late middle ages. We also detect 3%–5% sub-Saharan African ancestry in all eight of the diverse Jewish populations that we analyzed. For the Jewish admixture, we obtain an average estimated date of about 72 generations. This may reflect descent of these groups from a common ancestral population that already had some African ancestry prior to the Jewish Diasporas.

At the time Dienekes had a pretty strong critique of the paper: the authors assumed that Northern Europeans were an unadmixed reference population, when in fact these populations may have had mixture from East Asians. He presented PCA plots which illustrated the fact that CEU (whites from Utah with British and German ancestry) sample were shifted toward Chinese in comparison to Sardinians. All these years later I think that in fact there is another explanation besides East Asian admixture to explain this: the Chinese themselves have some admixture from West Eurasians. The Sardinians are notably lacking in some admixture components common among mainland Europeans, so the West Eurasian admixture into Chinese probably is closer to mainland Europeans than it would be to Sardinians.

So what about the Sardinian admixture from Africans? The same dynamic might be at play here: old admixture from “Early European Farmers” into Africans might explain why they’re closer to Africans.

But let’s assume that the Sardinian admixture from Africans is legitimate. What does that mean for estimates of ancestral derivation from continental populations than you see in the DTC personal genomics firms that report ancestry results? It can only mean that among people of Southern European ancestry a few percent of African ancestry is being “masked” because it is part of the reference population set. This came to my mind because a half Cuban friend of mine had ~2% African ancestry. Reasonable. When I checked by running unsupervised ADMIXTURE he had ~4%. Then I noticed that the Sardinian reference set was often in the 1-2% range. One explanation for the discrepancy then would be that a few percent of African ancestry in his genome was simply swallowed up by the reference population in the supervised learning framework.

 
• Category: Race/Ethnicity, Science • Tags: Admixture

1984-Big-Brother To me 1984 is really insightful not for its depiction of totalitarianism, but the way in which modern American democratic politics cynically re-imagine the past. I have always been intrigued by George H. W. Bush (and more broadly the politicians within the family) shifting from a pro-choice supporter of planned parenthood sympathetic to population control, to a conventional acolyte of New Right pro-life positions around 1980. Though some people bring this up occasionally, the reality is that there seems to be an agreement to act as if that past no longer exists (also, in the 1980s Jesse Jackson and Al Gore went from pro-life to pro-choice). Similarly, Hillary Clinton waited until 2013 to support gay marriage, after a decade opposing it. Privately I assume she supported gay marriage, but spoke against it for political expediency. When the winds had changed she shifted her public view, and now would no doubt condemn in visceral terms those who promoted a position that she herself held three years ago! A position held by most Democratic politicians in the aughts on cynical grounds of political necessity is now scourged by those same politicians as being beyond the pale.

51WPYFJQQmL._SX317_BO1,204,203,200_ Got Land of Two Rivers: A History of Bengal from the Mahabharata to Mujib after it was mentioned on Facebook. The more you know.

In The New York Times, Brussels Attacks Underscore Vulnerability of an Open European Society:

The cultural code of silence in the heavily immigrant district, as well as widespread distrust of already weak government authorities, has provided what amounts to a fifth column or forward base for the Islamic State.

This is in The New York Times. If Fox News said something like this the squealing about “Islamophobia” would never end. One thing that some have observed is that the terrorist networks in Belgium seem to be almost exclusively Moroccan, not Turkish. Also, there are many friends and family members involved. If you read Scott Atran’s work on terrorism these facts are not surprising. One of the most annoying things about Sam Harris’ New Atheism is that he talks as if the Koran magically transmutes normal people into ticking time bombs. The ethnographic data present a different picture, where Islamic terrorism takes root in tightly integrated social networks which exclude outsiders. As Peter Turchin says, a widening precipitation of the Islamic jihadi phenomenon was easy to predict as an outcome of the events of the past 15 years because of the historical-social premises of this civilization.

Thetippingpoint Though overall I’m not a big fan of Malcolm Gladwell, his book from 15 years ago, The Tipping Point: How Little Things Can Make a Big Difference, did describe a phenomenon which I think can shed some light on why Moroccan, but not Turkish, networks in Belgium are being sucked into the jihadi milieu. To some extent this is stochastic in terms of where the phenomenon begins, but once there is a large social network present to allow it to take off, then positive feedback loops kick in. There is a lot of talk about the causal factors for why some countries, such as Tunisia, send so many Muslims to fight for ISIS, while others, such as India, do not. There are some predictive variables here that are worth talking about, but some of it might just be random chance. But once participation in the Syria war on the side of ISIS becomes meritorious in one’s social network, then the dynamic might just feed back into itself if there are no dampening mechanisms.

Ethnic_composition_of_Muslim_AmericansWhich gets to one of the major reasons that American Muslims are probably underrepresented in international jihadi activity: they lack asabiyyah due to ethnic diversity. The chart to the left actually oversimplifies. Though South Asian Muslims share a lot culturally for example, there is definitely an “inner circle” of cohesion defined by Pakistanis and Urdu speakers from India into which Bengali or South Indian Muslims, for example, are not totally integrated. Converts for obvious reasons often create their own communities of affinity unless they marry into a family, while black Americans have a separate culture altogether. The ethnic diversity combines with economic diversity to fracture Muslim-American identity in a way that makes cultural complexes like that of Molenbeek, where underclass and working class Moroccan Muslims set the tone, or Tower Hamlets, where Bangladeshi Muslims from Sylhet set the tone, very rare. Even the town of Hamtramck, Michigan, where Muslims are demographically very notable in the aggregate, exhibits a lot of ethnic diversity within the religion. The importance of ethnic homogeneity as an amplifying effect can be seen in the Buffalo Six, who grew up in a tight-knit Yemeni-American community, or the “Minnesota men” who are routinely reported to have died fighting for the Al-Qaeda affiliated Al-Shabaab in Somalia, who come out of the Somali refugee community.

To not put too fine a point on it, I think the high frequency of snitching by American Muslims is a function of the low ethnic cohesion of the religion in the United States. This is one reason why arrival of refugee communities in toto is going to be a problem in Europe. Sweden, for example, has just imported a piece of Syria, not individual Syrians. Good luck with that.

I think it’s time for Twitter to admit that it is a specialized service and focus on its core constituency.

The Rise of Donald Trump. Important:

Many of Trump’s supporters are already convinced that mainstream America is against them. They believe, with justification, that they are mocked and ridiculed. And they are especially indignant that they are not allowed to voice their concerns about immigration, about Black Lives Matter, and about globalization and multiculturalism more broadly, without being called racists or bigots.

At minimum Trump will do better in the general elections than polls predict.

No evidence for extensive horizontal gene transfer in the genome of the tardigrade Hypsibius dujardini. “We show that the extensive horizontal transfer proposed by Boothby et al. was an artifact of a failure to eliminate contaminants from sequence data before assembly.” Oops!

Why won’t you pay to read? I’m lucky to have been paid to blog for many years (and thanks to Ron Unz in particular, obviously!). I’m also lucky that this is not, and has never been, my primary source of income. That gives me a lot of freedom to say whatever I want.

Speaking of which. “Disclosure notice,” I am joining Embark, a genomics firm which will focus on dogs for my “day job.” Also, I’m still finishing up my Ph.D., doing some consulting for Gene by Gene, and writing for publications now and then. On the last issue, please make sure to subscribe to my total feed, as I am pretty busy and might not remember to post stuff here as a link all the time. Here’s an article on what Embark aims to do: Doggie DNA startup wants to learn about human diseases from dog drool.

Researchers Find Fish That Walks the Way Land Vertebrates Do.

If you are interested, Support Gila monster research.

Also, I should be at the Evolution Meeting this June in Austin.

Millennial-scale faunal record reveals differential resilience of European large mammals to human impacts across the Holocene.

Adaptation in protein fitness landscapes is facilitated by indirect paths.

In Facebook’s Hometown, the First Responders Aren’t Local. One reason I’m leaving California is that it’s not really congenial for young families. I was talking to a friend whose family has been living in San Francisco for four generations, and we got to discussing real estate. Her family own houses because their roots are so deep in the region, and I told her it was critical to start building vertically if the area wanted newcomers to stay for the long haul. Her response was “but it would ruin the views.” My response was “views are why San Francisco is so expensive.” Basically if there was more vertical development allowed in the Bay area, as is common in an Asian city, then there’d be more housing supply. But regulatory, cultural, and contingent (i.e., stakeholders who dominate zoning boards and benefit from inflated rents and property values) make it almost impossible to change the situation in California.

It’s a great state, but if you are middle class, you had better be single, or dual-income-no-kids, or have deep roots in the state so you can inherit property your parents purchased when it was affordable to do so on less than $300,000 per year in income. Otherwise, come for your 20s if you are a professional, but move elsewhere to raise kids. Perhaps if you become wealthy you can move back to Carlsbad when you retire.

Biologists Have Learned Something Horrifying About Prairie Dogs. Vegetarians can be violent. Hitler was a vegetarian by the end of his life.

616wAHLvMaL._SY344_BO1,204,203,200_Romeo Dallaire in Rwanda. Is anyone surprised he had a soft spot for the RPF? What exactly was he supposed to do? This gives me an opportunity to promote Dancing in the Glory of Monsters: The Collapse of the Congo and the Great War of Africa. Great book that everyone should read, especially in light of what’s going on in Syria now.

It turns out there are no saints, though there are many sinners. Too often today the past and present gets reduced to Manichaean caricatures, but there’s a reason that Manichaeanism is a recurrent feature of religion, but it tends to whither over time. It doesn’t engage with reality, and appeals just to our hopes and idealism.

This is an important paper: Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population.

Minding the Beeswax. Farmers and bees have a long history together.

PCASO has already been great for collaboration/data sharing:

 
• Category: Miscellaneous • Tags: Open Thread

stardd1

warbefore Over then years ago The Genetic Legacy of the Mongols was published. This paper illustrated the surprising genetic effects that historical demographic events might have; the authors found that one particular Y chromosomal lineage was extremely common in Central Eurasia, and, that lineage exhibited an explosive growth over the past 1,000 years. Combined with the high frequency in the Khalkha Mongols in particular the natural inference made was that this lineage was reflective of the reproductive success of the group of warrior elites descended from Genghis Khan.

Some have been skeptical of this relationship. Part of this is due to ignorance or skepticism of what one can learn from genetics broadly among some scholars. In a discussion with John Horgan the cultural anthroplogist R. Brian Ferguson dismissed the possibility of something like the Genghis Khan modal haplotype. This makes sense. Here is a quote from George Orwell’s 1984:

Anything could be true. The so-called laws of Nature were nonsense. The law of gravity was nonsense. ‘If I wished,’ O’Brien had said, ‘I could float off this floor like a soap bubble.’ Winston worked it out. ‘If he thinks he floats off the floor, and if I simultaneously think I see him do it, then the thing happens.’ Suddenly, like a lump of submerged wreckage breaking the surface of water, the thought burst into his mind: ‘It doesn’t really happen. We imagine it. It is hallucination.’ He pushed the thought under instantly. The fallacy was obvious. It presupposed that somewhere or other, outside oneself, there was a ‘real’ world where ‘real’ things happened. But how could there be such a world? What knowledge have we of anything, save through our own minds? All happenings are in the mind. Whatever happens in all minds, truly happens.

Even cultural anthropologists who reject the “Post-Modern” tendencies common in the United states in this field often live at some remove from an enterprise where data dictates the set of plausible models about the world. If science fiction is a vision of the future conditioned on the priorities of the present, cultural anthropology is an ethnography of the present and history of the past conditioned on the ideological values of the present.

In 1984 the dictates of the present determine the past. One of the reasons it is useful to read Lawrence Keeley’s War Before Civilization: The Myth of the Peaceful Savage is that it serves as a record of the stated positions of many cultural anthropologists, and how they have evolved over the years in light of new evidence, without any acknowledgement that their past positions were obviously false. In a progressive conception of science error is essential for the field to slowly converge upon reality as it is over time. But one must admit that one has made errors, and is changing one’s views to match the facts. Often cultural anthropologists strike a pose that “we always knew/believed that.” Many cultural anthropologists have given upon on any pretense that learning about the world out there is possible, and at the extreme even meritorious.

The conclusions of The Genetic Legacy of the Mongols are more plausible in light of a paper which was published last year, A recent bottleneck of Y chromosome diversity coincides with a global change in culture. In the paper the authors show that a massive bottleneck and subsequent explosion of very common Y chromosomal lineages such as R1b and R1a seems to have occurred on the order of 5,000 years ago. The star-shaped phylogeny is not just the legacy of Genghis Khan.

How did this situation come to be? Read Andrew Currey’s Slaughter at the Bridge in Science. It’s riveting. Here are some interesting passages:

Before the 1990s, “for a long time we didn’t really believe in war in prehistory,” DAI’s Hansen says. The grave goods were explained as prestige objects or symbols of power rather than actual weapons. “Most people thought ancient society was peaceful, and that Bronze Age males were concerned with trading and so on,” says Helle Vandkilde, an archaeologist at Aarhus University in Denmark. “Very few talked about warfare.”

DNA from teeth suggests some warriors are related to modern southern Europeans and others to people living in modern-day Poland and Scandinavia

The precis: 3,200 years ago thousands of men clashed around a bridge in a narrow valley in northeast Germany near the Baltic sea. Hundreds of these men died. Their skeletons yield the facts that they were in their 20s, were often killed in the brutal manner that occurs in pitched battle, and isotope analysis suggests that most of them came from hundreds of kilometers away. Both DNA and analysis of their bones to infer their diet suggest that some were similar to modern Southern Europeans, and may have been Southern Europeans in terms of their provenance, though I do not discount that there were pockets of people who were similar to the descendants of the European European Farmers (EEF) who persisted down to that period.

What does this tell us? In The Shape of Ancient Thought, most of which was written decades ago, there are presumptions about the nature of transmission of ideas from civilized (e.g., Mesopotamian) to non-civilized (e.g., archaic Greeks and Vedic Aryans) peoples. But what these results, and books such as War Before Civilization, remind us that writing and literacy is only one of the aspects of complex human organization. Complex societies seem necessary for literacy, but literacy is not necessary for social complexity (E.g., the Inca domains). Keeley documents suggestive evidence of large-scale conflict between the first farmers to arrive in Central Europe and marine foragers along the coastal littoral thousands of years before the slaughter at the bridge. Rather than being the start of something new, I suspect what occurred at Tollense was the later stages of a tradition of preliterate conflict and competition which persisted down the period of Christianity.

 
• Category: History, Science • Tags: Europe, Genetics

A friend invited me to watch the new Batman v Superman: Dawn of Justice movie with him on a spur of the moment. I won’t say much about the film (it was OK, but way, way, too much prologue, and too little Wonder Woman). A bunch of us waited during the credits for teasers afterward. At some point an attendant came out, and told us that “this isn’t a Marvel film, there are no teasers….” I got up to leave but noticed that half the audience stayed in their seats as the attendant explained that he’d “watched the film twice already, there are no teasers. Really.” As I was exiting I looked back and it was clear that some people were stubbornly staying in their seats, and the attendant was cleaning up and mumbling there were no teasers and everyone should just go home now.

It’s going to be a long weekend for that guy.

 
• Category: Miscellaneous • Tags: Film

shape-ancient-thought-comparative-studies-in-greek-indian-thomas-mcevilley-hardcover-cover-art Reading The Shape of Ancient Thought. Not a light read, but worthwhile so far. I’m not a big fan of metaphysics in general, but the empirical patterns are interesting. Surprised at the likely Mesopotamian influence on both India and Greece, though in hindsight it makes sense. More to say on this later….

Some people are asking me about this Jeff Jacoby column, Sex is etched in our DNA, but race is all in our heads. Actually, everything is in our heads. Everything is socially constructed. It just so happens that some social constructions (e.g., gender binary) robustly map onto patterns in reality, while others (e.g., gender is purely a function preference) do not. The idea that “our racial and ethnic identities are purely subjective” seems to be pretty false if you think of it as a prediction you can use. Someone of my physical appearance could plausibly “pass” as a range of ethnic groups across the 10/40 Window, but no one is likely to accept that I’m ancestrally Chinese, Swedish, or Dinka.

Rakhigarhi ancient DNA paper probably a while away.

A suggestion for debaters. Basically, debate science in your own specialization and don’t claim broad knowledge you lack.

34% of my readers supported Donald Trump in the survey last month. Over 50% had graduate degrees. A bit lower than the average proportion for readers of this weblog, but not that much.

Poll: Utah would vote for a Democrat for president over Trump. I don’t accept this poll. I think Trump will get nominated, and he will win Utah. But, this poll, and results from Idaho, suggest that Mormons have a particular antipathy toward Donald Trump. Reiterates that though Southern Evangelicals and Mormons are allies in the political realm, there are deep cultural differences between the two groups.

Global median income has doubled in the last 13 years.

Article on why Bangladesh does so much peacekeeping. My cousin is in Bangui right now, so on my mind.

Stannis died in the show. How about the books? I guess we’ll know in the 2020s….

Statisticians issue warning over misuse of P values. R. A. Fisher warned about this.

Causes of molecular convergence and parallelism in protein evolution.

 
• Category: Science • Tags: Evolution, Genetics

lifesat

A new paper on which has some results on life satisfaction, intelligence and the number of social interactions one has has generated some mainstream buzz. For example, at The Washington Post, Why smart people are better off with fewer friends. I looked at the original paper: Country roads, take me home… to my friends: How intelligence, population density, and friendship affect modern happiness. The figure above shows the interaction effect between intelligence, life satisfaction, and number of times you meet up with friends over the week. What you see is that among the less intelligent more interactions means more life satisfaction and among the more intelligent you see the reverse.

webpreview_htm_ece4380546ed7237 But take a look at the y-axis. It cuts off at 4.10. The scale is: 1 = very dissatisfied, 2 = dissatisfied, 3 = neither satisfied nor dissatisfied, 4 = satisfied, and 5 = very satisfied. The effect here is very small. The less intelligent group had a mean IQ of 81. This is over 1 standard deviation below the norm, at about the 10th percentile. The intelligent had a mean IQ of 115, 1 standard deviation above the norm, so at the 84th percentile. When looking at the two groups divided between the prosocial (nearly 1 interaction per day) and antisocial (about 2 per week), the Cohen’s d for the low IQ was 0.05 and for the high IQ was 0.03. A d of 1 would mean one standard deviation difference between the two distributions in life satisfaction. In other words, the difference here is very minor.

The authors corrected for a bunch of variables, like sex, marital status, education, and ethnicity. But the data were from the NLSY, so the mean age was about 22. I wonder if the results would be different if you had an older age cohort. The authors themselves are quite guarded about their interpretation: “Given that our data are correlational and frequency of socialization with friends and life satisfaction were measured at the same time, we cannot rule out an opposite causal order to what we hypothesize, where happier people choose to socialize with their friends more frequently.”

The study may be reporting a true result, even if the effect is modest. But I’m quite confident that my inverted title may also be correct, though again, I suspect the effect will be modest. These are not actionable results for anyone. That is all.

 
• Category: Science • Tags: Psychology

Ron Unz is running for the United States Senate. One of the major reasons is that bilingual education might be restored in California via the California Multilingual Education Act. Here is state Senator Ricardo Lara in Senator Lara Announces Bill Supporting Multilingual Education:

Multiple studies have shown that supporting children’s home language in early years is critical to later academic achievement, and results in better outcomes than English-only approaches. Additionally, researchers have also found that it is not just English learners who benefit from instruction in two languages – children from English-only homes enrolled in such programs had a distinct reading advantage over their peers in English-only programs.

“Extensive research has shown that students who build strong biliteracy skills (in English and one or more other languages) have higher academic success, a foundation for increased salary earnings, and stronger cognitive skills as they grow older,” said Jan Gustafson-Corea CEO of the California Association for Bilingual Education. “CABE supports Senator Lara’s bill as one that will promote educational equity and excellence in our schools and create a pathway for success for all students in the 21st century.”

“English will always remain the official language of California, but we cannot ignore the growing need to have a multilingual workforce,” said Lara.

I have a personal story that I can bring to bear on this. I arrived in the United States with only rudimentary knowledge of English (my maternal grandmother taught me a bit before I came to this country). When I entered kindergarten at at 5 I was not fluent. By the end of kindergarten I basically knew English at the fluent level, and any perception that English might have been a second language was gone by the time I finished 1st grade. At home my parents continued to speak Bengali to me, a language in which my fluency remains at the level of a 5 year old (I’m also illiterate).

As a teaching assistant in the UC system I’ve encountered some older students who exhibit a peculiar linguistic profile. Almost always Latino, they have a very mild accent in English, but are basically verbally fluent. But they are shockingly less fluent in written English. My first “wake-up” call was on a final exam where a student of mine asked for the definition of a word. My initial thought was “Dude, I can’t define scientific words for you, that’s your job.” It was the word composition. This is not an isolated incident. I’ve learned not to infer written fluency from verbal fluency for Latino students who are old enough to have gone through bilingual education as it was practiced in California in the 1990s.

Jessica_Alba_SDCC_2014 Recently I had dinner with one of these students. He received an A in class. Born in the United States he is of Mexican American background. Though he has strong quantitative and analytic skills, his fluency in written English is not at the same level. Over dinner he explained why: he was in Spanish language classes until he was 13. He didn’t start reading English until he was a teenager, so written English is for him for all practical purposes a second language.

I put the word operationally in the title for a reason: there are forms of bilingual education which are fine, and redound to a students’ success. My brother-in-law was in a French language immersion school and he has no problem with the English. But the immersion schools that middle class American students experience are not the bilingual schools which are set up in California’s Central Valley.

I understand that there are studies which indicate multilingualism are beneficial cognitively. I’m mildly skeptical of these studies, but I don’t believe they speak to the sort of schools which will reemerge if bilingual education is brought back. Additionally, I am aware that enabling Mexican American children to learn English will not be a panacea for weak college preparation for a variety of reasons. It hasn’t been so far at least. But fostering an environment where these people are linguistically segregated is not going to help anything in the near future. Unless you are a particular type of multiculturalist who actually prefers a Balkanized society (or, a racialist).

 
• Category: Ideology • Tags: Bilingual Education

neaScience just published another paper on archaic admixture, Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals. It’s open access, so you should read it. And really, you should read the supplements. The paper is fine enough, but the space limitations are a real bummer here.

But what I want to talk about is Carl Zimmer’s write-up in The New York Times, Ancestors of Modern Humans Interbred With Extinct Hominins, Study Finds. It’s good, I have no quibbles with Carl’s journalism. I am just perplexed at the title (which he’s not responsible for). Why would you say “hominins” instead of humans? Because that’s what these distant lineages, which contributed some ancestry to our own, were, by any reasonable definition.

I have not given much thought to animal experimentation, though I am not comfortable personally with research on apes (I did read The Great Ape Project). I would definitely oppose research on sister hominin lineages if they were to be discovered alive in some obscure and isolated location, because they are human, even if they are different. There is some ambiguity in the science journalism right now as to what is or isn’t a human from what I can tell by the constant semantic fluidity. Often you finesse the issue by stating “modern human.” I think that’s fine. But we need to seriously think about collapsing the semantic distinction between these diverse lineages when it comes to their human status. Humanity as a characteristic is an ancestral trait of the hominin lineage, not a derived one.

 
• Category: Science • Tags: Evolution

I’ve been rather bearish on candidate gene studies of human behavior (e.g., “hug gene” or “violence gene”) since 2007. The reason being the influence of friends who warned me that a lot of false positive results were being published because they could be published. Basically you might have one group publish on a plausible candidate gene, and other groups would follow up and publish only when p < 0.05, neglecting all the null results.

I'm a believer that much of variation in behavior has a biological basis in terms of variation in genes. But I’m a believer in robust and replicable science which I have faith in. With that, Is there a publication bias in behavioral intranasal oxytocin research on humans? Opening the file drawer of one lab:

The neurohormone oxytocin (OT) has been one the most studied peptides in behavioral sciences over the past two decades. Primarily known for its crucial role in labor and lactation, a rapidly growing literature suggests that intranasal OT (IN-OT) may also play a role in humans’ emotional and social lives. However, the lack of a convincing theoretical framework explaining IN-OT’s effects that would also allow to predict which moderators exert their effects and when, has raised healthy skepticism regarding the robustness of human behavioral IN-OT research. The poor knowledge of OT’s exact pharmacokinetic properties, crucial statistical and methodological issues and the absence of direct replication efforts may have lead to a publication bias in IN-OT literature with many unpublished studies with null results lying in laboratories’ drawers. Is there a file drawer problem in IN-OT research? If this is the case, it may also be the case in our laboratory. This paper aims to answer that question, document the extent of the problem and discuss its implications for OT research. Through eight studies (including 13 dependent variables overall, assessed through 25 different paradigms) performed in our lab between 2009 and 2014 on 453 subjects, results were too often not those expected. Only five publications emerged from our studies and only one of these reported a null-finding. After realizing that our publication portfolio has become less and less representative of our actual findings and because the non-publication of our data might contribute to generating a publication bias in IN-OT research, we decided to get these studies out of our drawer and encourage other laboratories to do the same.

 
• Category: Science • Tags: Psychology

220px-BryanCaplanBryan Caplan, author of The Myth of the Rational Voter, and Selfish Reasons to Have More Kids, long ago expressed a desire to clone himself. To some extent I can understand the desire. There are many ways that my toddler son resembles me in terms of his behavior patterns that are uncanny. This allows me to gain insight into his thought process, and hopefully mentor him in a manner which would be more difficult if he wasn’t quite like me. The similarities we be even greater if he was a genetic clone. Personally, I am not inclined to clone myself because I get along very well with different types of people, and don’t have the impulse to encounter a literal mini-me. I’ve never, for example, regretted not having an identical twin. But to each his own.

I thought of Caplan when I read this article in New York Magazine, Paying $100,000 to Clone Your Dog Won’t Give You Your Dog Back:

Even still, sometimes the things you know with your head can’t compete with the comparatively dumb hopes of your heart. That NPR report referenced earlier included the story of Dr. Phillip Dupont and his wife, Paula, who run a veterinary clinic in Louisiana. The Duponts paid Sooam $100,000 to clone their dog Melvin, a pet they loved and trusted so deeply they even let the dog “babysit their grandson in the backyard all by himself.” The Duponts got three puppies out of the deal, though one of those puppies died. The other two are named Ken and Henry, and the couple is so happy with them they’re considering using Melvin’s DNA again — what better dog to give their grandson than one created with the DNA of his former babysitter?

It seems likely that over time the price point for cloning technologies will decline. It may be feasible for families to recreate, at least genetically, the same pet for generations using the original cell line. In Frank Herbert’s Dune series Duncan Idaho was resurrected over and over through an advanced form of cloning. And, if the need for continuity of identity is heritable, one can imagine clone lines of humans developing over time. This isn’t that far-fetched, there are many taxa where there are closely related clonal and sexual lineages. Similarly, one can imagine sexual random mating humans, and clonal lines who have sex only for pleasure.

 
• Category: Science • Tags: Clones

51WCMXOk9IL._SX382_BO1,204,203,200_A man’s discovery of bones under his pub could forever change what we know about the Irish:

But over the last decade, a growing number of scholars have argued that the first Celtic languages were spoken not by the Celts in the middle of Europe but by ancient people on Europe’s westernmost extremities, possibly in Portugal, Spain, Ireland or the other locales on the western edges of the British Isles.

Koch, the linguist at the University of Wales, for example, proposed in 2008 that “Celtic” languages were not imports to the region but instead were developed somewhere in the British Isles or the Iberian Peninsula — and then spread eastward into continental Europe.

Moreover, in recent years, some archaeologists have proposed that the traditional story of the Celts’ invasion was, in a sense, exactly wrong — the culture was not imported but exported — originating on the western edge of Europe much earlier than previously thought and spreading into the continent.

In a 2001 book, Cunliffe, the Oxford scholar, argued on the basis of archaeological evidence that the flow of Celtic culture was opposite that of the traditional view — it flowed from the western edge of Europe, what he calls “the Atlantic zone” — into the rest of the continent. In many places of the Atlantic zone, he notes, people were buried in passages aligned with the solstices, a sign that they shared a unified belief system.

“From about 5,000 B.C. onwards, complicated ideas of status, art, cosmology were being disseminated along the Atlantic seaways,” Cunliffe said, and that culture then spread eastward.

The paper they’re alluding to is Neolithic and Bronze Age migration to Ireland and establishment of the insular Atlantic genome.

 
• Category: Science • Tags: Celts

overall-diversity-final-new

The white man who runs Google

The white man who runs Google

The above graph shows the diversity of Silicon Valley firms. There is an under-representation of black Americans and people of Latino cultural backgrounds. But there are many people of Asian ethnic origins. Since “Asians,” defined as people who inhabit the sweep of land between the Indus and east and north toward the Amur river, compose about 50% of the world’s population, it seems that their representation is fair. As someone who has friends who work in Silicon Valley the Asian flavor of the area is pretty hard to avoid. Go to Cupertino, where Asians are ~2/3 of the population, and you’ll see what I mean. Everyone who has spent time in the Valley knows this. Everyone who has been to a Google cafeteria knows this.

But this group does not include most Americans, so they rely on the media to impart knowledge of this region of America. Films like The Social Network, shows like Silicon Valley. And of course journalists and journalism. I’m not one to dismiss mainstream journalism. I pay for both The New York Times and The Wall Street Journal. But what is going on with articles like this in Quartz, White men dominate Silicon Valley not by accident, but by design. White men dominate Silicon Valley??? What planet are these headline writers living on? Basically, they’re lying, because they have a narrative, and they’re fitting the facts to fit that narrative. Humans have biases, and they tend to fall into preferred narratives. I understand. But this is Pravda level misrepresentation.

Decreased life expectancy is a white privilege

Decreased life expectancy is a white privilege

Here’s a Mother Jones article: Silicon Valley Firms Are Even Whiter and More Male Than You Thought. Read the article, and you find this: “But among those people directly employed in technology positions at Bay Area tech firms, Asians have actually surpassed whites as the dominant racial group….” No. Shit. Sherlock.

Demographic denialism is a thing. And it’s especially strong on the political-cultural Left. For example, the “Model Minority Myth” is not a myth. Look at the statistics on health and wealth. Actually, if you buy the myth that it isn’t a myth, I’m 99% sure you won’t. Rather, you’ll read qualitative ethnographies of Hmong refugees and use that as an equal balance to the literal tsunami of H1-B’s pouring into this country… That’s exactly like reducing the experience of all white people to downtrodden folk in Appalachia. But the same sort who assert that the model minority is a myth because of Southeast Asian refugees wouldn’t dare express the idea that white privilege is a myth because of Appalachian poverty.

 
• Category: Ideology • Tags: Demographics

Screenshot from 2016-03-15 22-46-48Sometimes you don’t know what is real or not real. What do people really believe? Do they really believe what they say? Even if it’s clearly ridiculous? Probably internalized 1984 too much. Also, many of my white friends have admitted to me that in university contexts when talking about sensitive topics such as race they’ve basically memorized what to say, even if they basically have no agreement with what they assert. They know what the party line to please everyone is.

So this happened at my university. ASUCD draws criticism for sumo wrestling costumes at Block Party:

Among those activities was an attraction in which students could dress in sumo suits and wrestle each other. The activity immediately drew criticism from members of the student body, who accused ASUCD of fat shaming and culturally appropriating Japanese culture.

According to the students who raised this issue to ASUCD, the sumo suits trivialized Japanese culture and the history of Japanese rikishi or sumo wrestlers.

Once the issue was brought to ASUCD’s attention, ASUCD’s Executive Office, consisting of President Mariah Kala Watson, Vice President Gareth Smythe and Controller Francisco Lara, immediately issued an apology for the incident and commended the students that brought the issue to light.

“We’d like to apologize for any harm the ‘Sumo Suit’ may have caused you all. This lapse in judgment is completely ASUCD’s fault and responsibility alone,” said ASUCD’s Executive Office in a Facebook post. “We are thankful to the student who courageously brought this issue to our attention […] This was an egregious oversight and it will hopefully not happen in the future.”

Scott Tsuchitani, a Ph.D. student in cultural studies, believed the incident was evidence of the lack of awareness of the racism against Asian and Asian American students.

“My overall impression is that this conversation is in itself an expression of white supremacist anti-Asian structural racism. If people are genuinely concerned with the needs of Asian Americans, then why are Asian American voices not front and center in this conversation?” Tsuchitani said via email. “Instead, Asian Americans are treated as mute, hapless victims, devoid of agency, a.k.a. the ‘model minority’ stereotype. That is what I see being reinscribed by this conversation.”

Tsuchitani went on to say that he was not pleased by ASUCD’s apology and called for more action from the association.

“It is pitiful that the ASUCD would pathologize the so-called victims as in need of treatment instead of reflecting more deeply on what is needed to address ASUCD’s own failure in this situation,” Tsuchitani said. “From my limited perspective, I would suggest that the foremost need for treatment might well be for cultural competency training for ASUCD itself. That is much more relevant here than any Orientalist history of sumo wrestling.”

 

51FCNSFNR5L._SY344_BO1,204,203,200_Scott Tsuchitani is a smart guy. He has two master’s degrees in engineering already. He’s not getting his Ph.D. in cultural studies because that’s all he could do with his mind. The fact that intelligent people such as Scott Tsuchitani parrot this sort of weird gibberish as a form of symbolic performance, enacting scripts which navigate the discourse of hierarchical power relations, so as to assert superiority and agency over others, is indicative of an intellectual culture in advanced stages of putrefaction.

Another symptom of a culture near the end of its internally incoherent logic is that you can’t distinguish farce from sincere expressions of outrage. The article above alludes to “fat shaming.” It reports on this objection in a straight manner, assuming the sincerity of the complainant. Actually that student was trolling. It is reached such levels of self-parody that you can’t distinguish between the trolls and the truly offended, it’s all turning into a great game.

For those genuinely interested in Japanese culture, as opposed to being offended on behalf of Japanese culture, I recommend Maurius Jansen’s The Making of Modern Japan. Also, Moshi Moshi is much better than Zen Toro or Mikuni in my opinion.

 
• Category: Ideology • Tags: Cultural Appropriation

SHUpdate Ignore stuff on mutation rate. Confused mutation rate per year with per generation. Moral of story: read more closely! End update

The genetic data from the Sima de los Huesos (SH) hominins has finally been published in Nature. Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins:

A unique assemblage of 28 hominin individuals, found in Sima de los Huesos in the Sierra de Atapuerca in Spain, has recently been dated to approximately 430,000 years ago…While the Sima de los Huesos hominins share some derived morphological features with Neanderthals, the mitochondrial genome retrieved from one individual from Sima de los Huesos is more closely related to the mitochondrial DNA of Denisovans than to that of Neanderthals…Here we recover nuclear DNA sequences from two specimens, which show that the Sima de los Huesos hominins were related to Neanderthals rather than to Denisovans, indicating that the population divergence between Neanderthals and Denisovans predates 430,000 years ago. A mitochondrial DNA recovered from one of the specimens shares the previously described relationship to Denisovan mitochondrial DNAs, suggesting, among other possibilities, that the mitochondrial DNA gene pool of Neanderthals turned over later in their history.

I don’t want to denigrate mtDNA, but the whole field of phylogeography and inference of evolutionary relationships in non-human organisms has been confused by the fact that many scientists drew a straight-line between the genealogy of a single locus, mtDNA, and the genealogy of a whole species. In light of results from molecular ecology, which long relied on mtDNA, but is finally moving toward genome-wide marker sets because of new technologies, I’m absolutely not shocked that mtDNA is not particularly predictive of whole genome relatedness. Recall that the Denisovan hominin had an mtDNA lineage which was more distant from Neanderthals than the whole genome turned out to be.

More importantly for this paper is that they find that whole genome inferences suggest that the SH hominins are genetically closer to Neanderthals than they were to Denisovans. I’ll skip over their quality control of the ancient samples…the group that published this paper is the best in the business, and it’s broadly persuasive to me…though I don’t know much about this topic, so you shouldn’t put much weight on my opinion. Because of the small amount of data retrieved they used a rather simple method to establish relatedness: shared derived mutations. Basically these are unique mutations which distinguish particular hominin lineages from each other and the outgroup population (other primates).

The above figure shows that the the SH hominin samples share much more with Neanderthals than with Denisovans, and more with Denisovans than with modern humans. From that one might reasonably infer then that:

1) The ancestry of modern humans diverged before the SH-Neanderthal-Denisovan clade.

2) But Denisovans diverged rather quickly from the SH-Neanderthal clade.

3) Since the SH hominin site seems to date to ~400,000 years before the present, and is found in part of the traditional range of Neanderthals, and these individuals share morphological characteristics with this group, the SH hominins may be the ancestral population, or related to the ancestral population, of Neanderthals.

How robust is this date? I don’t know enough geology or paleontology to judge, so I won’t follow the citations. But a lot of the discussion and novelty of these results seems to hinge on this date. From the paper:

This age is compatible with the population split time of 381,000–473,000 years ago estimated for Neanderthals and Denisovans on the basis of their nuclear genome sequences and using the human mutation rate of 0.5 × 10−9 per base pair per year…This mutation rate also suggests that the population split between archaic and modern humans occurred between 550,000 and 765,000 years ago.

A more conventional mutation rate I’ve seen is closer to 1 to 2 × 10−8, or two to four times faster than the one above. But the mutation rate literature is rather confusing for me, and does not totally align well together, possibly due to variation in rate over time.

The picture above is often derived from a model where we fit the diversification of the human lineage to a tree. But within the paper they suggest Neanderthal mtDNA might have been African, and that there may have been an earlier migration out of Africa before the one that occurred ~50-100,000 years ago. I don’t see a priori why this couldn’t be so, but I’m also not clear how we’re going to get a good grasp of the details of the dynamics at play.

Perhaps the dominance of the African “Out of Africa” lineage over the last 100,000 years is an aberration. It may be that much of human history was characterized by the sorts of meta-population dynamics described by classical multi-regionalists. The possibility that Neanderthal-Denisovan divergence might be as old as ~450,000 years before the present suggests to me that the massive replacement and assimilation we saw ~50-100,000 years ago was somehow atypical in terms of how it disrupted deep regional population structure….

 
• Category: Science • Tags: Human Evolution
Razib Khan
About Razib Khan

"I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. If you want to know more, see the links at http://www.razib.com"